MORPHOMETRY DIFFERENTIATES FRAGILE X SYNDROME & CONTROL BOYS AGES 1-3

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 研究遗传性疾病，如脆性X综合征(FXS)，这是一种由单个基因突变导致的树突状和突触修剪异常的疾病，与健康人一起 可能为研究基因、脑-行为关系提供有价值的信息。 具体目的：研究儿童早期FXS与对照组的形态空间模式的区别。 方法：对101名1~3岁儿童、51名FXS儿童、32名典型发育迟缓(TD)儿童和18名特发性发育迟缓(DD)儿童进行体素形态计量学检查。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Studies of genetic disorders such as fragile X syndrome (FXS) which is a disorder caused a single gene mutation resulting in abnormal dendritic and synaptic pruning, together with healthy individuals may provide valuable information to study gene, brain-behavior relationship. Specific Aims: To examine morphometric spatial patterns that differentiate between FXS from controls in early childhood. Methods: Voxel-based morphometry was examined in a total of 101 children of ages 1 to 3; 51 boys with FXS, 32 typically developing (TD) boys and 18 boys with idiopathic developmental delay (DD).