COMPARATIVE GENOMICS OF PEROXISOMAL LIPID METABOLISM

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 自从人属出现以来，人类及其祖先与环境的相互作用发生了许多重大变化。其中一种互动涉及现代人迁出非洲之前肉类消费的急剧增加。我们假设人类和他们的祖先已经获得了脂肪代谢途径的适应性变化，以响应饮食的变化。基于已知的这些通路的生理重要性，这些选择性改变可能强烈地影响涉及神经、心血管系统和肝脏的复杂的人类表型。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Since the emergence of the genus Homo, there have been many significant changes in the interactions of humans and their ancestors with their environments. One such interaction involves dramatic increases in meat consumption prior to migrations of modern humans out of Africa. We hypothesize that humans and their ancestors have acquired adaptive changes in lipid metabolic pathways in response to dietary shifts. Based on the known physiological importance of these pathways, these selective changes could strongly influence complex human phenotypes involving the nervous and cardiovascular systems and liver.