HYPERPOLARIZED GAS IMAGING AT THE DIFFUSION LIMIT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们将开发多通道(1H/3He和129Xe/1H)3D径向编码，以扩散和磁化率极限所构成的空间分辨率对小鼠肺进行活体成像。 为了实现这一目标，我们将整合三项紧密结合的技术改进： --我们将在我们的成像链中集成一个双通道射频线圈，以实现@85和MHz的同时采集，以提高灵敏度。 -我们将安装新的更高强度梯度(400 Mt/m)，以减少扩散的影响。 --我们将优化3D(双通道)径向采集序列，以限制敏感性的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We will develop multi-channel (1H/3He and 129Xe/1H) 3D radial encoding for in vivo imaging of the mouse lung at the spatial resolution posed by diffusion and susceptibility limits. To achieve this aim, we will integrate three tightly coupled improvements in technology: -- We will integrate a dual-channel rf coil into our imaging chain for simultaneous acquisition @ 85 and 64 MHz to improve the sensitivity. -- We will install new higher strength gradients (400 mT/m) to reduce the impact of diffusion. -- We will optimize a 3D (dual-channel) radial acquisition sequence to limit the effects of susceptibility.