IMAGING OF MOUSE LUNG TUMORS WITH FLUORESCENCE TOMOGRAPHY / MICROCT

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 荧光断层扫描（FT）是一种高灵敏度的非侵入性临床前成像方法。随着我们最近方法学发展的成功，我们正在将新开发的技术转化为肺癌小鼠的临床前体内成像。我们以前已经成功地进行了研究，使用相同的动物模型与microCT，其中血管化的肿瘤显着增强，由于泄漏的血管在肿瘤。在拟议的研究中，我们计划测试荧光造影剂可以通过相同的机制用于增强肿瘤的假设。此外，由于生物分布的差异，我们还将比较荧光和X射线造影剂在肿瘤增强方面的差异。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Fluorescence tomography (FT) is a highly sensitive noninvasive method for preclinical imaging. With the success in our recent methodological development, we are translating the newly developed technology to preclinical in vivo imaging of mice with lung cancers. We have previously successfully conducted studies using the same animal model with microCT, in which vascularized tumors were significantly enhanced due to leakiness of the vasculature in the tumors. In the proposed study, we plan to test the hypothesis that fluorescent contrast agent can be used to enhance tumors via the same mechanism. In addition, due to the differences in biodistribution, we are also going to compare the differences in tumor enhancement using fluorescent and x-ray contrast agent.