NON-INVASIVE QUANTITATION OF CELLU & BIOCHEM CHANGES IN SPINOCEREBELLAR ATAXIAS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 (in与神经病学的KhalafBushara博士和芝加哥大学神经病学的ChristopherGomez博士合作，由R21 NS 056172、慈善基金和BobAllisonAtaxiaResearchCenter，PIOz支持：在这个项目中，我们研究了与脊髓小脑共济失调（SCA）中的神经变性相关的神经化学改变。目标是建立和验证与神经变性相关的多种细胞和生化事件的标记物，如神经元死亡，神经胶质增生和氧化应激。到目前为止，我们已经扫描了SCA 1、SCA 2、SCA 6、弗里德赖希共济失调、小脑多系统萎缩和共济失调伴动眼运动失用症2型的患者，以及年龄匹配的健康对照。我们通过高场核磁共振波谱（MRS）检测到共济失调的神经化学特征的改变，并发现这些改变对不同的共济失调亚型具有特异性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. (in collaboration with Dr.s Khalaf Bushara, Neurology and Christopher Gomez, University of Chicago, Neurology, supported by R21 NS056172, philanthropic funds and Bob Allison Ataxia Research Center, PI Oz): In this project we study the neurochemical alterations that are associated with neurodegeneration in spinocerebellar ataxias (SCAs). The goal is to establish and validate markers of multiple cellular and biochemical events associated with neurodegeneration, such as neuronal death, gliosis and oxidative stress. We have so far scanned patients with SCA1, SCA2, SCA6, Friedreich's ataxia, cerebellar multiple system atrophy and ataxia with oculomotor apraxia type 2, as well as age-matched healthy controls. We have detected alterations in the neurochemical profile in ataxias by high field nuclear magnetic resonance spectroscopy (MRS) and found that these are specific for different ataxia subtypes.