WATER SOLUABLE NUTRIENT ABSORPTION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：通过测量非人类灵长类动物对水溶性营养物质的被动吸收程度，更好地了解非人类灵长类的消化生理。 该项目对了解人类和非人类灵长类的消化生理学，以及了解脊椎动物的营养生态学和毒理学具有重要的意义。许多营养素、天然毒素和合成毒素和药物都是水溶性的。脊椎动物小肠中水溶性化学物质的有效运输可能依赖于膜运输蛋白(介导的运输)；然而，一些动物可以通过细胞之间的缝隙有效地运输这些化学物质(即通过被动的细胞旁途径)。我们使用生理学和药代动力学技术来测试灵长类动物被动吸收的程度。这项研究从2003年秋季开始，到2005年12月完成。 这项研究使用了WNPRC动物服务中心。 资金在本报告所述期间之前结束。有一份出版物正在等待出版。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To better understand the digestive physiology of non-human primates by measuring the extent of passive absorption of water-soluble nutrients. This project has important implications for understanding the digestive physiology of humans and non-human primates, and also for understanding vertebrate nutritional ecology and toxicology. Many nutrients, natural toxins and synthetic toxins and drugs are hydrosoluble. Efficient transport of hydrosoluble chemicals across the vertebrate small intestine likely depends on membrane transport proteins (mediated transport); however, some animals can efficiently transport these chemicals through the gaps between cells (i.e., by a passive, paracellular pathway). We used physiological and pharmacokinetic techniques to test the extent of passive absorption in primates. This study began during the fall of 2003 and was completed by December of 2005. This research used WNPRC Animal Services. Funding ended before this reporting period. One publication is pending.