LENS LASER STRATEGIES FOR PRESBYOPIA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：观察老年恒河猴透镜激光损伤前后中枢神经刺激的反应能力。 目前，接受透镜激光治疗的猴子被圈养以进行长期观察。 在此之前，将电极植入2只老年恒河猴的Edinger Westphal核中，以便可以中枢刺激调节。此外，4只年轻的恒河猴被用作测试对象来校准飞秒激光。 在确定透镜激光对屈光反应的影响之前完成基线测试。飞秒激光手术似乎在猴眼中耐受良好。然而，在5只接受激光治疗的猴子中，有2只观察到小的视网膜灼伤（大小为1-2 mm）。在激光照射后24小时开始的飞秒激光手术未损害使用Hartinger符合验光仪获得屈光测量的能力，并且动物未表现出异常行为或疼痛或不适的证据。 对其余4只恒河猴每半年进行一次裂隙灯检查。所有动物都保持正常视力。明年将对该项目进行重新评价，以确定一个适当的终点。 这项研究使用WNPRC研究服务。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To determine the accommodative ability in older rhesus monkeys following central stimulation before and after lens lasering. Currently, monkeys that received laser treatment of the lens are being housed for long-term observations. Previously, an electrode was implanted into the Edinger Westphal nucleus of each of 2 older rhesus monkeys so that accommodation could be stimulated centrally. In addition 4 young rhesus monkeys were used as test subjects to calibrate the femtosecond laser. Baseline testing was completed prior to determination of the effects of lens lasering on the accommodative response. The femtosecond laser procedure appears to be well tolerated in the monkey eye. However, small retinal burns (1-2 mm in size) were noted in 2 out of 5 monkeys lasered. The ability to obtain refractive measurements with the Hartinger coincidence refractometer was not compromised by the femtosecond laser procedure beginning 24 hours after lasering and the animals did not exhibit abnormal behavior or evidence of pain or discomfort. Slit lamp examinations are performed bi-annually in the remaining four rhesus monkeys. All animals maintain normal vision. Reevaluation of the project will be conducted in the upcoming year to determine a suitable end-point. This research used WNPRC Research Services.