ASSESSMENT OF COGNITIVE FUNCTION AND RELATIONSHIP TO REACTIVITY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 相当多的研究集中在糖皮质激素水平和认知能力之间的关系。 在人类中，由压力或糖皮质激素管理产生的高水平皮质醇对陈述性记忆，面部识别记忆和工作记忆有有害影响。 然而，很少有研究减少应激反应对认知表现的影响。 这类研究要么需要通过实验降低糖皮质激素水平，要么需要研究应激反应较低的人群。我们以前已经表明，与SIB猴子有较低的应激反应比对照组。 因此，他们提供了一个重要的模型，以测试是否自然发生的较低的压力反应与恒河猴的表现增加。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Considerable research has focused on the relationship between glucocorticoid levels and cognitive performance. In humans, high levels of cortisol produced by stressors or by administration of glucocorticoids have deleterious effects on declarative memory, face recognition memory, and working memory. However, there is little research on the impact of reduced stress reactivity on cognitive performance. Such research requires either reducing glucocorticoid levels experimentally or studying populations with lower stress reactivity. We have previously shown that monkeys with SIB have lower stress reactivity than controls. Thus, they provide an important model to test whether naturally occurring lower stress responsiveness is associated with increased performance in rhesus monkeys.