CONVECTION-ENHANCED DELIVERY OF THERAPEUTIC AGENTS TO THE PUTAMEN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：设计一种成功的用于人壳核内输注载药溶液的对流增强输注方案。 在这种情况下，成功意味着覆盖壳核和/或尾状核，对周围结构的覆盖最小。 这项特殊研究的目标是在恒河猴中开发这样一种方案，并为人类中类似方案的结果提供预测。 我们将估计使用此协议实现给定覆盖的可能性。我们还专门比较了目前提出的大脑交付方法。 我们已经建立了所有的输注方法，并正在使用术中成像在非人灵长类动物中进行常规输注和凝胶。 本研究使用WNPRC Assay Services和CPI。 出版物： J Kimmelman，A John伦敦，B Ravina，T Ramsay，M伯恩斯坦，A Fine，FW Stahnisch，ME Emborg，MD，启动针对帕金森病的侵入性首次人体试验：伦理考虑。 运动障碍。第24卷，第13期，2009年，第13页。18931901. 已提交另一份出版物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To design a successful convection-enhanced infusion protocol for human intra-putamenal infusions of solutions carrying drugs. Success means, in this context, covering the putamen and/or caudate nucleus, with minimal coverage of surrounding structures. The goal of this particular study is to develop such a protocol in rhesus monkeys, and to offer a prediction for the results of a similar protocol in humans. We will estimate the likelihood of achieving a given coverage using this protocol. We are also specifically comparing current proposed methods of brain delivery. We have established all the infusion methods and are performing routing infusions and gels in nonhuman primates using intraoperative imaging. This research used WNPRC Assay Services and CPI. PUBLICATION: J Kimmelman, A John London, B Ravina, T Ramsay, M Bernstein, A Fine, FW Stahnisch, ME Emborg, MD, Launching Invasive, First-in-Human Trials Against Parkinson's Disease: Ethical Considerations. Movement Disorders. Vol. 24, No. 13, 2009, pp. 18931901. Another publication has been submitted.