International Aldosterone Conference - Cardiovascular

描述（由申请人提供）：我们正在申请支持2011 - 2015年的一系列年度会议，称为国际醛固酮会议-心血管。这些会议的目的是扩大对科学的理解-从细胞到人类-醛固酮和矿皮质激素受体激活在增加心血管风险方面的作用，包括广泛的心血管疾病，如高血压，糖尿病，肥胖，睡眠呼吸暂停，代谢综合征，心脏病，中风和肾功能障碍。这一目标将通过采用国际醛固酮会议的方法和形式来实现。这种方法在过去已经成功地实现了一个类似的目标，即在上皮细胞（例如肾脏）中矿皮质激素受体的激活机制。这种形式包括每年举行一次会议，为期五年。每次年会将包括三个半天的会议。每次会议都由一位最先进的演讲者开始，他是与醛固酮相关的特定学科的专家，但他本身并不是醛固酮方面的专家。与会者是醛固酮/矿皮质激素受体生理学、病理生理学、临床试验、生物化学、分子和细胞生物学、遗传学等领域的专家和研究人员。鼓励该领域的年轻研究人员参加。这一系列会议的结果将更好地理解激活醛固酮/矿皮质激素受体系统产生的不良心血管效应的潜在因素。随着了解的增加，将会有更好的方法来预防和/或治疗心血管疾病。

DESCRIPTION (provided by applicant): We are requesting support for a series of annual conferences from 2011 - 2015 to be called the International Aldosterone Conference-Cardiovascular. The objective of these conferences is to expand the understanding of the science - from cells to humans - underlying the role of aldosterone and mineralocorticoid receptor activation in increasing cardiovascular risk across a broad range of cardiovascular diseases, e.g., hypertension, diabetes mellitus, obesity, sleep apnea, metabolic syndrome, heart disease, stroke and renal dysfunction. This objective will be accomplished by using the approach and format of the International Aldosterone Conference. This approach has been successful in the past to accomplish a similar objective directed at the mechanism of activation of the mineralocorticoid receptor in epithelial cells, e.g., in the kidney. The format consists of an annual meeting for five years. Each annual meeting will consist of three half-day sessions. Each session begins with a state-of-the-art speaker who is an expert in a specific discipline related to aldosterone but who is not per se and expert in aldosterone. The attendees are experts and researchers in aldosterone/mineralocorticoid receptor physiology, pathophysiology, clinical trials, biochemistry, molecular and cellular biology and genetics. Young investigators in the field are encouraged to attend. The outcome from this series of conferences will be better understanding of the factors underlying the adverse cardiovascular effects produced by an activated aldosterone/mineralocorticoid receptor system. With this increased understanding will come better approaches to prevent and/or treat cardiovascular diseases.