Understanding health disparities in cervical dysplasia and cancer through the ide

项目摘要 宫颈癌仍然是发展中国家妇女癌症死亡的主要原因之一。 国家。在美国，当按种族分层时，非裔美国人和西班牙裔女性两者都有 宫颈癌的发病率和死亡率高于高加索妇女。这些差距存在于 部分原因是获得医疗保健和筛查，但即使在考虑到这一点后，非裔美国人 而西班牙裔女性的死亡率仍然较高。这份赠款申请描述了 潜在的生物标记物可能有助于开始了解疾病进展的差异 非裔美国人、西班牙裔、高加索女性宫颈癌前病变阶段。这个 这种生物标志物的识别将有助于确定观察到的差异的生物学基础 宫颈癌的发病率和死亡率。此外，这些生物标志物将有助于 在众多出现巴氏试验异常的女性中，找出少数处于兴奋状态的女性 罹患癌症的风险。这将大大降低发病率和成本。 节省巴氏试验后续程序，同时提供更好、更积极的护理 那些真正需要它的人。

Project Summary Cervical cancer remains one of the leading causes of cancer mortality in women in developing nations. When stratified by race in United States, African American and Hispanic women have both higher incidence and mortality from cervical cancer than Caucasian women. These disparities are in part due to access to healthcare and screening, but even after accounting for this, African American and Hispanic women continue to have higher mortality rates. This grant application describes potential biomarkers that may help begin to understand the differences in progression of the preneoplastic stages of cervical cancer between African American, Hispanic, Caucasian women. The identification of such biomarkers will help determine the biological basis for the observed disparities in the incidences as well as mortality of cervical cancer. In addition, these biomarkers will be useful to identify, among the many women who present with Pap test abnormalities, the few that are at high risk of developing cancer. This will allow for considerable reduction in morbidity as well as cost savings in Pap test follow-up procedures, at the same time providing better, more aggressive care to those who truly need it.