DEVELOPMENTAL RESEARCH PROGRAM

生物信息学核心的总体作用是为SPORE研究人员提供生物信息学支持 服务这些服务包括高通量数据（微阵列和序列）处理和分析， 通常涉及统计和概率分析，开发专门的软件和数据库， 进行计算机模拟。不涉及高通量数据的分析（例如，临床相关性）将 由SPORE Biostatistics Core执行。 生物信息学核心的具体目标是 1.为了从全局Illumina和Affyphase基因表达生成基因表达特征， 微阵列 2.通过一个基因表达标签来描述基因表达标签的生物学特征和预后能力， 广泛的功能和途径分析。 3.从全局和靶向Agilent阵列比较中生成拷贝数改变（CNA）图谱 基因组杂交（aCGH）微阵列。 4.设计针对特定癌症相关基因和途径的定制Agilent aCGH阵列。

The overall role of the Bioinformatics Core is to provide SPORE investigators with bioinformatics support services. These services include high-throughput data (microarray and sequence) processing and analysis, often involving statistical and probabilistic analyses, developing ad hoc software and databases, and performing computer simulations. Analyses not involving high-throughput data (e.g., clinical correlations) will be performed by the SPORE Biostatistics Core. The specific aims of the Bioinformatics Core are 1. To generate gene expression signatures from global lllumina and Affymetrix gene expression microarrays. 2. To describe the biological characteristics and prognostic ability of gene expression signatures through a wide range of functional and pathway analyses. 3. To generate copy number alteration (CNA) profiles from global ahd targeted Agilent array comparative genomic hybridization (aCGH) microarrays. 4. To design custom Agilent aCGH arrays that target specific cancer-associated genes and pathways.