Factors Influencing the Survival of Implant-Supported All-Ceramic Prostheses

描述(由申请者提供)：这个以患者为导向的研究职业发展奖旨在为Josephine Esquivel-Upshaw博士提供一个从事临床研究的机会，该研究旨在分析材料科学参数和生物力学因素对控制植入支持的全陶瓷假体存活的影响。埃斯奎维尔博士自西北大学口腔修复住院医生以来一直从事陶瓷研究，并作为NIDCR少数民族补充补助金和行业支持补助金的一部分，继续从事实验室和临床陶瓷研究。这项拟议的研究项目将在肯尼斯·J·阿努萨维奇博士的指导下，在佛罗里达大学牙科学院口腔修复研究生诊所进行。Esquivel-Upshaw博士的直接职业目标包括扩展她在陶瓷方面的材料科学知识，使她能够在良好的材料背景下进行与临床相关的研究项目。她的长期职业目标包括继续她作为佛罗里达大学修复学系教员的学术生涯，并能够竞争性地申请联邦政府资助的独立奖项，最终成为一名受人尊敬的临床科学家。研究职业发展计划包括注册课程，这些课程将把Esquivel-Upshaw博士的陶瓷和研究背景提升到一个更高的水平。这些课程将包括断裂学、陶瓷微结构、表面分析方法和扫描电子显微镜的使用。其他正式课程还将提供有关临床研究、流行病学、生物统计学和拨款撰写等法律和伦理问题的指导。研究项目包括分析种植全瓷假体的断裂韧性、弹性模量、芯体厚度、连接件高度、磨损量和最大咬合力，以及它们对假体设计和存活的影响。这项研究与公共卫生的相关性在于，它将使临床预测和临床研究结果得以证实，为全瓷假体的设计和应用提供可靠的生物力学指南。这些信息对于告知牙科团体至关重要的变量对牙体的影响、抗折性和牙釉质磨损、使用的适应症和禁忌症以及最佳的制造方法是必不可少的。

DESCRIPTION (provided by applicant): This Mentored Patient-Oriented Research Career Development Award is intended to provide Dr. Josephine Esquivel-Upshaw an opportunity to engage in clinical research aimed at analyzing the influence of materials science parameters and biomechanical factors that control the survival of implant-supported all-ceramic prostheses. Dr. Esquivel has been involved in ceramics research since her Prosthodontic residency at Northwestern University and has continued with laboratory and clinical ceramic research as part of an NIDCR minority supplement grant and an industry supported grant. The proposed research project will be conducted at the University of Florida College of Dentistry, Graduate Prosthodontic Clinic under the mentorship of Dr. Kenneth J. Anusavice. Dr. Esquivel-Upshaw's immediate career goal includes expanding her materials science knowledge in ceramics to enable her to conduct clinically relevant research projects with a sound materials background. Her long term career goal includes continuing her academic career as a faculty member in the Department of Prosthodontics at the University of Florida and being able to competitively apply for an independent federally funded award to eventually become a respected clinical scientist. The research career development plan includes enrollment in courses that will enhance Dr. Esquivel-Upshaw's ceramics and research background to an advanced level. These courses will include fractography, ceramic microstructure, surface analytical methods and the use of Scanning Electron Microscopy. Other formal courses will also offer instruction on legal and ethical issues of clinical research, epidemiology, biostatistics and grant writing. The research project involves analysis of fracture toughness, elastic modulus, core thickness, connector height, wear, and maximum clenching force on implant-supported all-ceramic prosthesis and their effect on the design and survival of these prostheses. The relevance of this research to public health is that it will enable clinical predictions and confirmation by clinical research findings to provide reliable biomechanics guidelines for the design and application of all-ceramic prostheses. Such information is essential to inform the dental community of the influence of critically important variables on, fracture resistance and enamel wear, the indications and contraindications for use, and optimal methods of fabrication.