2012 DNA Damage, Mutation & Cancer GRC

描述（由申请人提供）：人类细胞不断暴露于外源性和内源性DNA损伤源，导致突变，从而导致癌症。2012年DNA损伤、突变和癌症戈登研究会议的总体目标是了解突变如何导致人类癌症。这与美国国立卫生研究院的使命有关，特别是NCI和NIEHS我们的目标是了解DNA损伤如何导致导致人类癌症的突变，从而努力改进预防和治疗人类癌症的策略。这一目标将通过组织和主持一个多学科会议来实现，该会议旨在解决DNA损伤、突变和遗传不稳定机制以及遗传不稳定与人类癌症之间关系的不同研究领域。在DNA损伤的修复和处理、基因组不稳定性和癌症病因学方面的分子机制方面的前沿研究将被介绍。涵盖的主题包括DNA结构和诱变机制，端粒生物学和遗传不稳定性，DNA修复缺陷综合征和癌症，通过病变旁路修复损伤或耐受的途径，染色质介导的基因组不稳定性，以及靶向DNA修复途径在癌症治疗中的有前途的策略。初级调查人员将有机会通过口头报告和海报展示来展示他们的工作。例如，在32位受邀演讲者中，有5位是初级调查员。我们将根据摘要中描述的最及时、最令人兴奋的工作，从摘要中选择另外14位演讲者。我们期待会议上的科学交流将对癌症研究产生重大影响，并导致建立新的多学科合作努力。2012年DNA损伤、突变和癌症戈登研究会议将于2012年3月25日至30日在加州文图拉海滩举行。为了实现为会议设定的目标，为会议提供资金支持是极其必要的。资助的重点将是那些原本无法参加会议的发言者、初级调查员发言者，并鼓励妇女和代表性不足的少数民族的参与。

DESCRIPTION (provided by applicant): Human cells are constantly exposed to both exogenous and endogenous sources of DNA damage that lead to mutations, which can result in cancer. The overall goal of the 2012 DNA Damage, Mutation & Cancer Gordon Research Conference is to understand how mutations lead to human cancer. This is relevant to the mission of the NIH, and in particular the NCI, and NIEHS in that we aim to understand how DNA damage leads to mutations that result in human cancer, in an effort to improve strategies to prevent and treat human cancer. This goal will be achieved by organizing and hosting a multidisciplinary conference designed to address diverse research areas focused on DNA damage, mechanisms of mutagenesis and genetic instability, and the relationships between genetic instability and human cancer. Cutting edge research will be presented on the molecular mechanisms involved in the repair and processing of DNA lesions, genome instability, and cancer etiology. Topics to be covered include DNA structure and mutagenic mechanisms, telomere biology and genetic instability, DNA repair deficiency syndromes and cancer, pathways for damage repair or tolerance through lesion bypass, chromatin-mediated genomic instability, and promising strategies for targeting DNA repair pathways in cancer therapy. Junior investigators will be afforded the opportunity to present their work both by oral presentations and poster presentations. For example, of the 32 invited speakers, 5 are junior investigators. We will select (from the abstracts) an additional 14 speakers based on the most timely, and exciting work described in the abstracts. We expect that the scientific exchange at the conference will impact cancer research in significant ways and result in establishing new multi-disciplinary collaborative efforts. The 2012 DNA Damage, Mutation & Cancer Gordon Research Conference will be held in Ventura Beach, California from March 25-30, 2012. Awarded funding support for the meeting is critically necessary in order to achieve the goals set forth for the conference. Funding priorities will be for speakers who would otherwise be unable to participate in the meeting, junior investigator speakers, and to encourage the participation of women and underrepresented minorities. PUBLIC HEALTH RELEVANCE: In human cells, the DNA is constantly under attack by DNA damaging agents that can cause DNA damage that leads to mutations, which are involved in cancer etiology. The overall goal of the 2012 DNA Damage, Mutation & Cancer Gordon Research Conference is to understand how mutations lead to human cancer. This is relevant to public health because we aim to understand how DNA damage leads to mutations that result in human cancer, in an effort to improve strategies to prevent and treat human cancer.