SPORE in Skin Cancer

匹兹堡大学和匹兹堡大学癌症研究所提议在皮肤癌领域开展一项卓越研究专业项目（SPORE）。匹兹堡大学皮肤癌孢子的总体目标是提高皮肤癌的检测和治疗。SPORE项目将由6个皮肤癌转化研究项目、行政核心项目、发展研究项目、职业发展项目等4个核心项目组成。匹兹堡大学皮肤癌孢子将采用跨学科的方法，通过与基础、应用和临床科学的共同研究人员开展项目来实现其目标。它还具有器官特异性，因为它的方法和所有项目都将测试有关皮肤癌生物学、易感性、检测或治疗的假设。长期的转化研究项目，将作为改善诊断为皮肤癌的患者的结果的基础。六个主要项目包括：(1)萝卜硫素化学预防黑色素瘤；(2)多种抗原工程DC免疫与干扰素？促进转移性黑色素瘤；(3)极化树突状细胞引导黑色素瘤特异性反应；(4)黑色素瘤及其肿瘤相关血管表达EphA2的治疗性免疫靶向；(5)描述影响烷基化剂治疗黑色素瘤疗效的DNA修复途径；(6)利用T-regs耗竭增强树突状细胞免疫治疗seary综合征。这四个研究核心将密切互动，协助主要研究项目、发展性研究项目和职业发展研究者开展转化性皮肤癌研究。研究核心有：核心A.行政核心；B.组织芯；免疫监测和细胞产物实验室（IMCPL）；核心D.生物静力学。行政核心将征求内部和外部科学咨询委员会的反馈意见，并为SPORE项目提供科学、管理和财政监督。Skin SPORE研究人员将共同努力，协同实现该计划的目标，并将与其他机构的孢子研究人员互动，以改善皮肤癌患者的预后。

The University of Pittsburgh and University of Pittsburgh Cancer Institute propose to conduct a Specialized Program of Research Excellence (SPORE) in Skin Cancer. The overall goals of the University Pittsburgh Skin Cancer SPORE are to improve the detection and treatment of skin cancer. The SPORE program will consist of six translational research projects in skin cancer, four cores including an administrative core, a developmental research program and a career development program. The University of Pittsburgh Skin Cancer SPORE will use an interdisciplinary approach to meet its objectives by carrying out projects with co- investigators in basic, applied and clinical science. It is also organ-specific in that its approach and all projects will test hypotheses about skin cancer biology, susceptibility, detection, or treatment. The long-term translational research projects that will serve as the basis for improving the outcome of patients diagnosed with skin cancer. The six main projects include: (1) Chemoprevention of Melanoma with Sulforaphane; (2) Multiple Antigen-Engineered DC Immunization and IFN? Boost for Metastatic Melanoma; (3) Polarized Dendritic Cells Guide Melanoma-Specific Responses; (4) Therapeutic Immune Targeting of EphA2 Expressed by Melanoma and Its Tumor-Associated Vasculature; (5) Delineating the DNA Repair pathways impacting alkylating agent efficacy in the treatment of Melanoma; (6) Augmentation of Dendritic Cell-based Immunotherapy for Sezary Syndrome by T-regs depletion. The four research cores will interact closely to assist the main research projects, developmental research projects and the career development investigators in carrying out translational skin cancer research. The research cores are: Core A. Administrative Core; Core B. Tissue Core; Core C. Immunological Monitoring and Cellular Products Laboratory (IMCPL); Core D. Biostatics. The Administrative Core will solicit feedback from the Internal and External Scientific Advisory Boards and provide scientific, regulatory and fiscal oversight for the SPORE program. The Skin SPORE investigators will work together to synergistically achieve the goals of the program and will also interact with investigators from SPOREs at other institutions to improve the outcome of patients with skin cancer.