Pacific Ovarian Cancer Research Consortium

太平洋卵巢癌研究联盟（POCRC）是一个以社区为基础的多学科转化研究计划，涉及来自太平洋沿岸六个研究和医疗机构的临床医生，实验室科学家和公共卫生科学家。以社区为基础的方法允许汇集临床资源，以促进基于人群的研究，尽管卵巢癌的发病率很低。该计划的主题是疾病风险和早期检测的生物标志物，预后和治疗的分子靶点以及免疫治疗的抗原。我们假设，通过早期检测，我们可以显着改善结果，因为目前可用的治疗方法对局限于卵巢的疾病更有效;新的，毒性较小的免疫治疗方法预计在早期疾病中特别有效。POCRC将开展5个转化研究项目，包括使用在临床前样本中验证的血清标志物在高危女性中进行筛查试验，使用靶向微泡改善超声性能的新型成像试验，验证microRNA血浆特征的可接受性，探索恢复野生型BRCA 1功能在发展对顺铂的耐药性中的作用，以及抗lGFBP 2疫苗的1期试验。每个项目至少涉及SPORE指南中概述的一个翻译领域，并且该计划涉及TRWG定义的6个翻译途径中的5个，所有项目都建立在当前和以前资助期间进行的工作基础上。发展研究计划和职业发展计划也包括作为我们的更新的一部分。项目由领导和管理核心，临床标本管理和表征核心，参与者招募，注册和表征核心以及生物统计和数据管理核心支持。

The Pacific Ovarian Cancer Research Consortium (POCRC) is a community-based, multidisciplinary, translational research program that involves clinicians, laboratory scientists and public health scientists from six research and medical institutions on the Pacific Coast. The community-based approach allows the pooling of clinical resources to facilitate population-based studies despite the low incidence of ovarian cancer. The themes of the program are biomarkers for risk and early detection of disease, molecular targets for prognosis and therapy, and antigens for immunotherapy. We hypothesize that through early detection we can improve outcomes significantly because currently available treatments are more effective in disease confined to the ovary; new, less toxic immunotherapeutic approaches are expected to be particularly effective in early-stage disease. The POCRC will conduct 5 translational research projects including a screening trial in high-risk women using serum markers validated in preclinical samples, a novel imaging trial using targeted microbubbles to improve ultrasound performance, validation of a microRNA plasma signature for respectability, exploration of restoration of wild-type BRCA1 function in the development of resistance to cicplatin, and a Phase 1 trial of an anti-lGFBP2 vaccine. Each project addresses at least one of the translational areas outlined in the SPORE guidelines and together the program addresses 5 of the 6 translational pathways defined by the TRWG, All projects build on work performed during the current and previous funding periods. A Developmental Research Program and a Career Development Program are also included as part of our Renewal. Projects are supported by a Leadership and Administration Core, a Clinical Specimen Management and Characterization Core, a Participant Recruitment, Enrollment and Characterization Core, and a Biostatistics and Data Management Core.