CLINICAL TRIAL: DANCE DANCE REVOLUTION (DDR)

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 2型糖尿病是一种常见的糖尿病，也是一种常见的糖尿病。在美国，像我们机构所服务的少数民族群体不成比例地受到肥胖和2型糖尿病的影响2，3。尽管现在有各种各样的药物治疗，但全国大约一半的糖尿病患者的血红蛋白A1 c（HbA 1c）水平仍高于7%。ADA建议所有糖尿病患者每周定期进行至少150分钟的中等强度有氧运动。持续的运动训练以剂量依赖性和快速的方式改善葡萄糖摄取和血糖控制6，7，在一次剧烈运动后12小时内即可证明8。然而，如果运动刺激不被维持，则其也是相对短暂的，在运动计划突然停止后约72小时内胰岛素敏感性丧失9，10。即使在体重或肥胖没有变化的情况下，胰岛素敏感性的改善也可以重现，如持续时间较短的研究11，12所示。长期保持有规律的身体活动不仅有助于减肥和减少肥胖，而且还可以改善多种心血管风险因素13-18，心血管和总体死亡率19-24，一些非代谢性疾病25-31，以及心理社会特征32-35。运动处方可以定制以适应患者的独特偏好和生活方式，这导致改善的长期依从性36。与其他疗法相比，与自我发起的身体活动计划相关的直接成本也可能是有利的。 具体目标1：比较自我运动游戏与自我平板运动对成人2型糖尿病患者血糖控制变化的影响。 具体目标#2：比较自我发起的运动游戏与自我发起的跑步机运动对2型糖尿病成人患者的身体组成、有氧适能、心血管危险因素、体力活动的出勤率和可持续性以及运动行为的心理相关性变化的影响 糖尿病。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. An estimated 21 million people in the United States are affected by type 2 diabetes mellitus 1. In the U.S., ethnic minority groups like those served by our institution are disproportionately affected by obesity and type 2 diabetes 2, 3. Despite the wide array of pharmacological treatments now available, roughly half of all diabetic patients nationwide still have a hemoglobin A1c (HbA1c) level above 7% 4. The ADA recommends that all diabetic patients engage regularly in a minimum of 150 minutes per week of moderate-intensity aerobic activity 5. Sustained exercise trainingimproves glucose uptake and glycemic control 6, 7 in a dose-dependent and rapid fashion, demonstrable within as little as 12 hours after a single bout of intense exercise 8. However, it is also relatively transient if the exercise stimulus is not maintained, with a loss of insulin sensitization within ~72 hours after abrupt cessation of an exercise program 9, 10. The improvement in insulin sensitivity can be reproducibly demonstrated even in the absence of changes in body weight or adiposity, as shown in shorter-duration studies 11, 12. Chronic maintenance of regular physical activity not only contributes to weight loss and reduced adiposity, but also improves multiple cardiovascular risk factors 13-18, cardiovascular and overall mortality 19-24, a number of nonmetabolic \conditions 25-31, and psychosocial traits 32-35. Exercise prescriptions can be customized to suit a patient's unique preferences and lifestyle, which leads to improved long-term compliance 36. Direct costs associated with self-initiated physical activity programs may also be favorable compared to other therapies. Specific Aim #1: To compare the effects of self-initiated exergaming versus self-initiated treadmill exercise on changes in glycemic control in adult patients with type 2 diabetes mellitus. Specific Aim #2: To compare the effects of self-initiated exergaming versus self-initiated treadmill exercise on changes in body composition, aerobic fitness, cardiovascular risk factors, attendance and sustainability of physical activity, and psychological correlates of exercise behavior, in adult patients with type 2 diabetes mellitus.