DBE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 研究设计、生物统计学和临床研究伦理学(DBE)： 研究设计、生物统计和临床研究伦理(DBE)的关键职能作为一种机制，为合理的研究设计、生物统计、数据管理和研究伦理提供集中支持，以便将基础和临床研究转化为实践和政策。通过整合联盟成员机构的努力，DBE将得到加强和扩展，使更多的研究人员能够获得支持，并参与DBE和波多黎各临床和转化性研究联盟合作伙伴的合作。这些调查员将在研究项目的不同阶段与DBE保持密切沟通，包括：研究设计、抽样设计、样本量和能量计算、随机化方案、数据库开发和验证、数据录入、数据管理和质量控制、数据库维护和数据分析。 此外，DBE将在拨款提案撰写、科学编辑和拨款续签等领域提供支持。为了加强对研究的参与和提高生产率，DBE将建立网络，将初级和中级调查人员与其他领域的研究人员进行匹配，并提供讲习班、研讨会和专题讨论会，以支持DBE人员和调查人员。DBE的总体目标将是加强和巩固现有的研究基础设施，以促进机构内部和多学科或跨学科的合作，从而扩大波多黎各翻译研究的生产力。更具体地说，DBE将通过以下方式积极帮助实现波多黎各临床和转化性研究联盟的目标： 1.为红十字会资助的项目和其他资金来源使用设施的项目提供咨询支持。 2.提供研究设计、生物统计学和临床研究伦理方面的培训机会。 3.组织年度特邀演讲者，就新的研究设计、统计和方法问题进行专题演讲，以加速将基础和临床研究转化为实践和政策。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Research Design, Biostatistics and Clinical Research Ethics (DBE): The Research Design, Biostatistics and Clinical Research Ethics (DBE) key function works as a mechanism to provide centralized support for sound research design, biostatistics, data management and research ethics for translating basic and clinical research into practice and policy. The DBE will be enhanced and extended through the integration of efforts from Consortium-member institutions, allowing more investigators to receive support and to engage in collaborations with the DBE and Puerto Rico Clinical and Translational Research Consortium partners. These investigators will be in close communication with the DBE at different stages of research projects including: study design, sampling designs, sample size and power calculations, randomization schemes, database development and validation, data entry, data management and quality control, database maintenance, and data analysis. In addition, the DBE will offer support on areas such as grant proposal writing, scientific editing, and grant renewal. In order to enhance participation in research and productivity, the DBE will foster networks to match junior and mid-level investigators with researchers in other fields and offer workshops, seminars, and symposia to support investigators and DBE personnel. The overall goal of the DBE will be to enhance and consolidate the existing research infrastructure to facilitate intra-institutional and multi- or inter-disciplinary collaborations that can expand the productivity of translational research in Puerto Rico. More specifically, the DBE will actively contribute to help accomplish the aims of the Puerto Rico Clinical and Translational Research Consortium by: 1. Provide consulting support to PRCTRC funded projects and projects with other sources of funding which use facilities. 2. Provide training opportunities in research design, biostatistics and clinic research ethics. 3. Organize annual featured guest speakers working on novel research design, statistical and methodological issues approaches for accelerating the translation of basic and clinical research into practice and policy.