P30 - CENTER CORE GRANT FOR VISION RESEARCH

描述(由申请人提供)：这项加州大学圣地亚哥分校(UCSD)愿景研究核心拨款提案将在4个不同的实质性领域提供关键资源，以利用NEI资助的加州大学圣地亚哥分校研究人员的专业知识，并加快他们从NIH资助的研究中的发现。15名调查人员总共有18个NEI资助的合格R01项目。这些来自加州大学圣迭戈分校眼科、病理学、儿科、基因组医学研究所、放射学和心理学的研究人员代表了一群令人印象深刻的、多产的和合作的视觉研究人员。加州大学圣迭戈分校的VISION研究人员涵盖了所有级别的教员任命和研究成果，从9名在各自领域处于领先地位的全职教授到6名最近招聘的初级教员(Annese博士、Balasubramanian博士、Bosworth博士、Huberman博士、Ju博士、Lin博士)。此外，来自其他NIH研究所和基金会的大量资金(表2)进一步突显了加州大学圣地亚哥分校VISION研究计划的实力。特别是，我们的产品组合在人类和动物成像和功能评估、图像分析、流行病学/临床研究、遗传学、青光眼、AMD、视网膜变性、细胞生物学、分子生物学、动物模型和血管生物学方面实力雄厚。 加州大学圣迭戈分校眼科在青光眼和视网膜研究方面有着悠久的优秀传统。随着最近NEI资助的七名研究人员(Ayagari博士、La Spada博士、Lin博士、Ju博士、Zhang博士，以及最近的Balasubramanian博士和Huberman博士)的招聘，UCSD的视觉研究已经达到了临界点，这将受益于协调、增强和利用每位参与研究人员的专业知识的基础设施，从而使整个UCSD视觉研究界受益。目前，9名NEI资助的研究人员在相邻且相互连接的Shiley眼科中心(SEC)、汉密尔顿青光眼中心(HGC)和雅各布斯视网膜中心(HRC)设有办公室和实验室。毗邻的两个研究中心(汉密尔顿青光眼中心和雅各布斯视网膜中心)包括26,000平方英尺的专门研究和办公空间。SEC还提供广泛的计算机/IT支持和独立的医疗记录服务，以及礼堂和图书馆。另有6名NEI资助的研究人员在加州大学圣地亚哥分校的主校区和毗邻的健康科学研究中心设有办公室(距离眼科不到5分钟的车程)。主校区包括来自部门的视觉研究人员。心理学(MacLeod博士)、生物学(Rainegel博士)、神经科学(Huberman博士)和生物工程(Silva博士)。健康科学综合大楼包括基因组医学研究所、斯卡格斯药物科学大楼(张博士和La Spada博士)、家庭和预防医学系的生物统计和生物信息学部门和生物统计研究中心(BRC)(Jain博士)，以及BSB基础科学大楼和毗邻的医疗教学设施MTF，其中容纳了Lin、Ju、Freeman、Bartsch和Weinreb博士的动物护理设施和动物实验室。此外，加州大学伯克利分校愿景研究核心将利用加州大学伯克利分校计算科学、数学和工程中心CSME培训计划的独特工程和计算专业知识。计算机科学(David Kriegman教授)和数学系(Michael Hoist教授-见支持函)，加州电信和信息技术研究所(CALIT2-其任务是加强“数字未来的协作研究环境”，详情见http://www.calit2.net/)(Larry Smarr教授-见支持信))，以及圣地亚哥超级计算机中心的资源，以加强目前的研究努力，并将现有的合作(例如，青光眼-数学-CALIT2协作)扩展到更广泛的愿景研究界。该应用程序的总体目的是提供共享资源，以提高和加快加州大学圣迭戈分校视觉研究社区的生产率。以下4个单元将提供每个调查员目前无法获得或难以单独获得的重要新资源和服务。每个单元都有两个联合主任(每个人都有NEI ROI资金)，或者一名主任和助理主任(具有对该模块有价值的具体专业知识)，以确保行政管理，以便无论一名主任的差旅或其他承诺如何，问题都能得到及时解决。此外，每个模块的工作人员将提供直接服务(如统计分析、计算机编程、组织学)，还将培训调查人员及其工作人员完成任务，以便尽可能有效地利用模块资源，以最大限度地提高生产率。 公共卫生相关性：UCSD视力研究核心将提供最先进和创新的方法作为共享资源，促进合作，使我们更接近预防和治疗青光眼、黄斑变性和糖尿病视网膜病变等致盲眼病的目标。

DESCRIPTION (provided by applicant): This University of California, San Diego (UCSD) Vision Research Core grant proposal will provide critical resources in 4 distinct substantive areas to leverage the expertise of NEI funded UCSD investigators and to accelerate discoveries from their NIH funded studies. 15 investigators have a total of 18 NEI funded eligible R01 projects. These investigators from the UCSD Departments of Ophthalmology, Pathology, Pediatrics, Institute for Genomic Medicine, Radiology, and Psychology represent an impressive, productive, and a collegial group of vision researchers. UCSD vision researchers encompass all levels of faculty appointments and research accomplishments, from 9 full professors who are leaders in their respective fields to 6 recently recruited junior faculty (Drs. Annese, Balasubramanian, Bosworth, Huberman, Ju, Lin). Moreover, the substantial funding from other NIH institutes and foundations (Table 2) further highlights the strength of UCSD's vision research program. In particular, our portfolio is strong in human and animal imaging and functional assessment, image analysis, epidemiology/clinical research, genetics, glaucoma, AMD, retinal degeneration, cell biology, molecular biology, animal models, and vascular biology. The UCSD Department of Ophthalmology has a long tradition of excellence in glaucoma and retina research. With the recent recruitment of seven additional NEI funded investigators (Drs. Ayyagari, La Spada, Lin, Ju, Zhang, and most recently Balasubramanian and Huberman), vision research at UCSD has reached a critical mass that will benefit from an infrastructure to coordinate, enhance and leverage the expertise of each participating investigator to benefit the entire UCSD vision research community. Currently, 9 NEI funded investigators have offices and laboratories in the adjacent and interconnected Shiley Eye Center (SEC), Hamilton Glaucoma Center (HGC) and Jacobs Retina Center (HRC). The two adjoining research centers (Hamilton Glaucoma Center and Jacobs Retina Center) comprise 26,000 sq ft of dedicated research and office space. The SEC also provides extensive computer/IT support, and independent medical record services, as well as houses an auditorium and library. Another 6 NEI-funded investigators have offices nearby (less than a 5 minute drive from the Dept of Ophthalmology) at the main UCSD campus and adjoining Health Sciences research complex. The main campus includes vision researchers from the Depts. of Psychology (Dr. MacLeod), Biology(Dr. Rainegel), Neuroscience (Dr. Huberman) and Bioengineering (Dr. Silva). The Health Sciences complex includes the Institute for Genomic Medicine, Skaggs Pharmaceutical Sciences Building (Drs. Zhang and La Spada), the Division of Biostatistics and Bioinformatics and Biostatistics Research Center (BRC) in the Department of Family and Preventive Medicine (Dr. Jain) and the Basic Science Building-BSB with adjoining Medical Teaching Facility-MTF which house the animal care facilities and animal laboratories of Drs. Lin, Ju, Freeman, Bartsch, and Weinreb. Moreover, the UCSD Vision Research Core will leverage the unique engineering and computational expertise of UCSD's Center for Computational Sciences, Mathematics, and Engineering¿CSME training initiative. Computer Science (Prof David Kriegman) and Math Department (Prof Michael Hoist - see letter of support), the California Institute of Telecommunications and Information Technology (CALIT2- whose mandate is to enhance the "collaborative research environment for the digital future" for details see http://www.calit2.net/) (Prof Larry Smarr- see letter of support), and the resources of the San Diego Supercomputer Center to enhance current research endeavors and extend existing collaborations (e.g., Glaucoma-Math-Calit2 collaboration) to the broader vision research community. The overall purpose of this application is to provide shared resources to enhance and accelerate the productivity of the vision research community at UCSD. The following 4 modules will provide important new resources and services that are currently unavailable or difficult for each investigator to obtain individually. Each module has either 2 Co-Directors (each with NEI ROI funding), or a Director and Assistant Director (with specific expertise valuable to the module) to ensure administrative coverage so that issues can be addressed in a timely manner regardless of travel or other commitments by one of the Directors. In addition, the personnel for each module will both provide direct services (e.g. statistical analyses, computer programming, histology) and also train investigators and their staff to complete tasks so that module resources are utilized as efficiently as possible for maximum productivity. PUBLIC HEALTH RELEVANCE: The UCSD Vision Research Core will provide the most advanced and innovative methods as shared resources to foster collaboration and to bring us closer to our goal of the prevention and cure of blinding eye diseases such as glaucoma, macular degeneration, and diabetic retinopathy.