Growth Hormone and Cardiovascular Disease

描述(申请人提供)：这项建议的科学目标是调查相对生长激素缺乏和替代对腹型肥胖男性和女性身体成分和心血管风险标记物的影响。这项申请的职业发展目标是通过为研究和指导活动提供足够的时间，支持应聘者作为临床研究员和初级教师的专业发展，并在以患者为导向的临床研究中成功地指导他们。该应用程序的指导目标是促进临床研究方面的研究员和初级教师的培训，以形成独立职业生涯的基础。该候选人的NHLBI资助的R01赠款将调查生长激素替代对相对生长激素缺乏的内脏脂肪男性和女性的身体成分和心血管风险标记物的影响，这将成为该赠款的培训计划的基础。更多的研究机会以正在进行的研究的形式提供，这些研究由许多其他来源资助。该候选人在国家层面的指导方面具有领导能力，并在马萨诸塞州综合医院(MGH)内分泌奖学金计划和其他学科指导学员方面取得了成功的记录。麻省理工学院的制度环境非常出色，拥有强大而多样的医学系、哈佛医学院的临床转化科学中心拨款和临床研究计划。麻省理工学院的医学部已经做出了实质性的承诺，包括90%的保护时间和专用空间，以促进候选人作为临床研究人员的发展，负责培训研究员和初级教员。以患者为中心的研究生涯中期研究员奖是一种理想的机制，可以确保获得必要的支持，以减少临床和管理责任，并确保候选人作为导师和临床研究人员继续取得成功。 项目简介：心血管疾病是发达国家主要的死亡和疾病原因。这项建议调查了低生长激素水平作为一种可能的激素机制所起的作用，这可能是腹型肥胖症患者心血管风险增加的原因，因此可能对公众健康产生重大影响。

DESCRIPTION (provided by applicant): The scientific goal of this proposal is to investigate the effects of relative growth hormone deficiency and replacement on body composition and cardiovascular risk markers in men and women with abdominal obesity. The career development goal of this application is to support the candidate's professional development as a clinical investigator and successful mentor for fellows and junior faculty in patient-oriented clinical research by providing sufficient time for research and mentoring activities. The mentoring goal of this application is to facilitate the training of fellows and junior faculty in clinical research to form the basis of independent careers. The candidate's NHLBI-funded R01 grant investigating the effects of growth hormone replacement on body composition and cardiovascular risk markers in viscerally adipose men and women with relative growth hormone deficiency will form the basis for the training plan of the grant. Additional research opportunities are available in the form of ongoing studies that are funded by a number of other sources. The candidate has a record of leadership in mentoring on a national level and a successful track record of mentoring trainees in the Massachusetts General Hospital (MGH) Endocrine Fellowship program and other disciplines. The Institutional environment at the MGH, with a strong and diverse Medicine Department, Clinical Translational Science Center grant through Harvard Medical School, and Clinical Research Program, is outstanding. The Department of Medicine at the MGH has made a substantial commitment, including 90% protected time and dedicated space, toward the candidate's development as a clinical researcher responsible for training fellows and junior faculty. The Midcareer Investigator Award in Patient Oriented Research is an ideal mechanism to ensure the necessary support to reduce clinical and administrative responsibilities, and ensure the candidate's continued success as a mentor and clinical researcher. Project Narrative: Cardiovascular disease is the leading cause of death and illness in developed countries. This proposal investigates the role of low growth hormone levels as a possible hormone mechanism underlying the increased cardiovascular risk in women and men with abdominal adiposity and thus could have significant public health implications.