Molecular Regulation of Cell Development and Differentiation

描述(由申请者提供)：申请资金为堪萨斯大学医学中心(KUMC)的生物医学研究卓越中心(Cobre)续期五年。Cobre的研究重点是细胞发育和分化的调控。在最初的5年任期内，6名初级研究人员从科布雷大学毕业，所有人都成为了成功的独立研究人员。五名新的初级调查人员加入了该中心，我们的目标是帮助他们也成为独立资助的调查人员。为实现这一目标，已经组建了一名PI、两名共同PI、一个内部咨询委员会(Lac)、一个强大的指导教员小组和一个由杰出调查人员组成的外部咨询委员会(EAC)。该中心还旨在改善KUMC的研究基础设施。预期的结果将是提高研究生产力，如联合出版物和基于发育生物学主题的赠款支助所反映的那样。为每一位新入职的调查员分配了一名导师，并制定了个人辅导计划和生产率时间表。指导计划的主要特点包括由导师对研究项目进行持续的批判性评估，半年一次的会议，以及关于科学写作的专门培训。我们期望我们目前的初级教员在加入Cobre后的3年内，能够成功地从NIH或其他国家拨款机构获得R01级的支持。一旦获得资金，他们将停止为新教师腾出拨款空间，我们得到了部门主席/中心主任的坚定承诺，他们将提供这些新人。另一个重要特点是维护3个科学核心，为中心所有教职员工提供研究支持。除了管理和指导核心A，还有支持转基因的核心(核心B)、分子图谱(核心C)和高分辨率成像(核心D)。杰出的科学人才、研究环境和重大的机构承诺的杰出结合，确保该科布雷将继续促进专题、多学科研究的发展，并增强新研究人员竞争NIH支持的能力。

DESCRIPTION (provided by applicant): Funds are requested to renew a Center of Biomedical Research Excellence (COBRE) at the University of Kansas Medical Center (KUMC) for an additional five year period. This COBRE has a research focus on the regulation of cell development and differentiation. During the initial, 5 year term, 6 Beginning Investigators graduated from the COBRE, and all are becoming successful, independent researchers. Five new Beginning Investigators have joined the Center and our goal is to help them become independently funded investigators as well. A PI, two co-PIs, an Internal Advisory Committee (lAC), a robust group of mentoring faculty, and an External Advisory Committee (EAC) of distinguished investigators have been assembled to achieve this goal. The Center is also designed to improve the research infrastructure at KUMC. The expected outcome will be more research productivity as reflected in joint publications and grant support based on a developmental biology theme. A Mentor has been assigned to each of the new Beginning Investigator faculty recruits, and individual mentoring plans and productivity timetables have been developed. Central features of the mentoring plans include ongoing critical evaluation of research projects by Mentors, semiannual conferences, and special training on scientific writing. We expect that each of our current junior faculty members will compete successfully for R01-level support from the NIH or other national granting agency within 3 years of joining the COBRE. Once funded, they will cycle off the grant making room for new faculty, and we have firm commitments from Department Chairs/Center Directors who will provide these recruits. Another important feature is the maintenance of 3 scientific Cores to provide research support to all of the Center's faculty. Together with an Administrative and Mentoring Core A, there are Cores supporting transgenesis (Core B), molecular profiling (Core C), and high resolution imaging (Core D). The outstanding combination of exceptional scientific talent, research environment, and substantial institutional commitment, ensure that this COBRE will continue to foster the development of a thematic, multidisciplinary research effort and enhance the ability of new investigators to compete for NIH support.