Biomedical adhesives with precisely engineered surface topography and chemistry

描述（由申请人提供）：医学上需要一种粘接剂，这种粘接剂可以牢固地粘接在软组织和切口上，促进愈合并最大限度地减少炎症。这些材料可以潜在地减少手术时间，组织处理，并减轻并发症，如感染。虽然存在许多组织粘接剂，但由于机械性能不足、炎症增加和难以应用于某些伤口几何形状等限制，它们的应用受到限制。我们最近开发了一种具有生物相容性的纹理组织胶带，具有可调的机械、降解和粘合性能。对组织的功能测试显示，最大粘附强度为0.8 N/cm2，但为了将这些材料转化为医疗应用，粘附强度需要~5-15 N/cm2。在这个提案中，我们的目标是开发一种粘合牢固的粘合剂，可以应用于各种组织。我们将揭示制造具有明确表面形态和化学成分的生物界面粘合剂所需的基本科学和工程原理，而不会引起明显的炎症反应。通过增强我们现有的纳米结构胶带的粘附性，并通过阐明影响不同组织粘附的机制，所提出的研究将为发现新科学提供一个潜在的平台，从而为外科手术提供许多实际和有用的补充。具体来说，通过在微纳米尺度上控制生物相容性聚合物的表面特征，并系统地发展对地形、孔隙度和化学如何影响与生物组织的粘附性的理解，将开发出一类新的强粘附性微/纳米纹理生物材料。通过使用柔软、有弹性的材料，纹理表面应该很容易符合不规则形状的表面，如软组织，从而最大化分子在界面上的相互作用。

DESCRIPTION (provided by applicant): There is a significant medical need for an adhesive that can bond strongly to soft tissues and incisions that facilitates healing and minimizes inflammation. These materials can potentially reduce operating time, tissue handling, and mitigate complications such as infection. While numerous tissue adhesives exist, their applications are restricted due to limitations such as insufficient mechanical properties, increased inflammation and difficulty in application to certain wound geometries. We have recently developed a textured tissue tape that is biocompatible with tunable mechanical, degradation and adhesive properties. Functional testing against tissue showed maximum adhesion strength of 0.8 N/cm2, but in order to translate these materials to medical applications, adhesion strengths of ~5-15 N/cm2 are required. In this proposal, we aim to develop an adhesive that bonds strongly and can be applied to a variety of tissues. We will reveal the fundamental scientific and engineering principles required to fabricate biologically interfacing adhesives with well-defined surface morphologies and chemistries without inducing a significant inflammatory response. Through enhancing the adhesion of our existing nanostructured tapes and through elucidating mechanisms that impact adhesion to different tissues, the proposed research will provide a potential platform for discovery of new science that leads to many practical and useful additions to the surgical armentarium. Specifically, a new class of strongly adhesive micro/nano textured biomaterials will be developed by controlling the surface features of biocompatible polymers on the micro and nanoscale, and by systematically developing an understanding of how topography, porosity, and chemistry influence adhesion to biological tissues. Through using soft, flexible materials, the textured surfaces should easily conform to irregularly shaped surfaces, such as soft tissue, thereby maximizing molecular interactions at the interface. PUBLIC HEALTH RELEVANCE: The aim of this proposal is to develop a novel tissue tape (i.e. an internal bandage) through engineered substrate topography and chemistry that can satisfy the current medical demand for an adhesive that can bond strongly to tissue and facilitate the wound healing process. The development of this novel biomedical material will have broad implications for wound repair of many tissues including gut, bladder, lung, dura, and muscle. Potential benefits include reduction in operating time, tissue handling, and mitigation of surgical complications such as infection by eliminating the need for sutures.