Alaska INBRE-2: Environmental Agents and Disease

描述(由申请人提供)：阿拉斯加INBRE-2的这项提案旨在加强和扩大我们在阿拉斯加的生物医学研究和培训网络，并确保它是自我维持的。INBRE-2研究建立在INBRE-1取得的进展的基础上，以充实阿拉斯加在基础细胞生物学以及环境中的化学和微生物病原体方面的专业知识，包括禽流感和图拉热症等新出现的传染性人畜共患病。这些微生物学和毒理学主题与阿拉斯加强大的生态项目相互作用。布林和INBRE聘请了7名教师，他们的研究和教学生涯起步良好，已经成功竞争联邦研究拨款。生物信息学/计算核心和仪器支持将继续是阿拉斯加大学(UA)所有校区生命科学项目的资产。INBRE-2的主要投资集中在额外的7名教员、学生、教员设置、合作研究伙伴关系(包括与州公共卫生实验室的联合任命)、研究的行政支持和教育推广。我们的INBRE教师社区包括INBRE-1雇用的那些人，正在成为生物医学研究合作者的其他附属UA教员，以及填补微生物学、毒理学、细胞生物学和研究的临床翻译应用方面的空白的新雇员。 其中一位新科学家是阿拉斯加大学系统生物医学研究的执行董事。INBRE倡议与UA的倡议平行，并与UA的主线优先事项和不断发展的治理紧密联系在一起。阿拉斯加INBRE网络有两个主要节点，分别位于UAA(安克雷奇)和UAF(费尔班克斯)。INBRE与州公共卫生部、其他较小的大学单位、K-12教育、医疗服务社区以及西北地区的合作者建立了合作伙伴关系。它支持研究生奖学金和本科生研究奖励，并使让学生意识到校园研究机会的过程正规化。它继续资助博士后研究员，并鼓励他们融入加州大学的学术文化。它资助和促进了一系列针对大学预科学生的项目，特别是那些阿拉斯加原住民占多数的农村学生。我们帮助、培训和指导学生在高中做研究，在暑期课程中学习现代生物学，过渡到大学，在大学做研究，并申请研究生培训。将阿拉斯加农村的学生吸引到大学的教育渠道可以成为双向渠道，鼓励这些社区更好地教授我们他们所知道的和他们需要的东西。 公共卫生相关性(由申请者提供)：阿拉斯加INBRE涉及全球卫生优先事项：新出现的传染病病原体、对食品质量和安全的污染物影响、招募土著人民从事卫生事业以及将板凳生物医学科学与生态学相结合。阿拉斯加是大气污染物的倾倒地，也是东西半球之间新出现的人畜共患病病原体交流的交叉点。通过建设生物医学能力，我们使阿拉斯加有能力应对禽流感等新威胁。

DESCRIPTION (provided by applicant): This proposal for Alaska INBRE-2 aims to strengthen and expand our Alaska network for biomedical research and training and to ensure that it is self-sustaining. INBRE-2 research builds on the advances made in INBRE-1 to fill out Alaska expertise in basic cell biology and in chemical and microbial disease agents from the environment, including emerging infectious zoonotic diseases like avian influenza and tularemia. These microbiology and toxicology themes interface with the strong ecology programs in Alaska. BRIN and INBRE hired 7 faculty who are well-started on their research and teaching careers and are already competing successfully for federal research grants. The bioinformatics/computational core and instrumentation support will continue to be assets for programs across the life sciences on all campuses of the University of Alaska (UA). Major INBRE-2 investments focus on 7 additional faculty, students, faculty setups, collaborative research partnerships (including joint appointments with state public health labs), administrative support for research, and educational outreach. Our INBRE faculty community includes those hired by INBRE-1, other affiliate UA faculty who are becoming collaborators in biomedical research, and new hires to fill in gaps in microbiology, toxicology, cell biology, and clinical-translational applications of research. One of the new scientists is an executive director for biomedical research for the Alaska university system. INBRE initiatives parallel UA's own and are tightly linked to mainline UA priorities and evolving governance. The Alaska INBRE network has two major nodes, at UAA (Anchorage) and UAF (Fairbanks). INBRE has partnerships with: the State Department of Public Health, other smaller college units, K-12 education, the health delivery community, and collaborators in the Northwest region. It supports graduate fellowships and undergraduate research awards and formalizes the process of making students aware of on-campus research opportunities. It continues to sponsor postdoctoral fellows and to encourage their integration into the UA's academic culture. It funds and facilitates a suite of programs for pre-college students, particularly those in rural villages where Alaska Natives are in majority. We assist, train, and counsel students to do research in high school, to learn modem biology in summer courses, to transition to college, to do research in college and to apply for post-graduate training. The educational pipeline that draws students from rural Alaska toward the university can become a two-way conduit that encourages these communities to better teach us what they know and what they need. PUBLIC HEALTH RELEVANCE (provided by applicant): Alaska INBRE addresses global health priorities: emerging infectious agents, contaminant impacts on food quality and safety, recruitment of indigenous peoples into health careers, and integration of bench biomedical science with ecological perspectives. Alaska is a dump-site for atmospheric contaminants and the cross-over point for exchanges of emerging zoonotic agents between eastern and western hemispheres. By building biomedical capacity, we make Alaska competent to respond to new threats like avian influenza.