Elucidating links between ADHD symptoms and tobacco/alcohol use trajectories

摘要 烟草和酒精的使用会产生许多不利的健康后果，尽管烟草的途径 以及从青春期早期到成年的酒精使用，而最能预测这些途径的因素不是 很好理解。注意力缺陷多动障碍（ADHD）吸烟和使用 酒精的比例高于没有ADHD的人。此外，ADHD症状（即，多动症- 冲动[HI]，注意力不集中[IN]）低于临床诊断所需的阈值会增加 吸烟。更清楚地了解这些症状之间的发展关系 领域和物质使用有可能阐明吸烟的潜在病因和问题 饮酒以及告知治疗和预防方法在两个临床组和一般 人口使用传统和创新/先进的分析方法确定人口亚组 物质使用的动态特性（因子混合模型、潜曲线模型和增长混合模型 模型），我们将分析包含HI和IN症状史信息的现有纵向数据 烟草和酒精使用的结果。将使用两个具有国家代表性的数据库（国家数据库）。 青少年健康纵向调查-附加健康及收入动态追踪调查-儿童 发展补充/向成年过渡- PSID-CDS/TA）。调查小组在以下方面具有专长： ADHD、成瘾、行为流行病学和纵向数据分析等领域， 进行拟议的研究。成功完成此提案将使您获得更精确的知识 关于HI和IN症状对从青春期到青年期的物质使用的影响。 这些知识对于有效的预防性干预规划和实施是必要的。

Abstract Numerous adverse health consequences arise from tobacco and alcohol use, though the pathways of tobacco and alcohol use from early adolescence into adulthood and the factors that best predict these pathways are not well understood. Individuals diagnosed with Attention Deficit Hyperactivity Disorder (ADHD) smoke and use alcohol at higher proportions than those without ADHD. Moreover, ADHD symptoms (i.e., hyperactivity- impulsivity [HI], inattention [IN]) below the threshold necessary for clinical diagnosis increase the risk of cigarette smoking. A clearer understanding of the developmental relationship between these symptom domains and substance use has the potential to elucidate the potential etiology of smoking and problem drinking as well as inform treatment and prevention approaches in both clinical groups and in the general population. Using traditional and innovative/advanced analytic methods for identifying population subgroups and dynamic properties of substance use (factor mixture modeling, latent curve modeling, and growth mixture modeling), we will analyze extant longitudinal data that contains information on history of HI and IN symptoms and tobacco and alcohol use outcomes. Two nationally representative databases will be used (The National Longitudinal Survey of Adolescent Health-Add Health and Panel Survey of Income Dynamics - Child Development Supplement/Transition to Adulthood - PSID-CDS/TA). The investigative team has expertise in the areas of ADHD, addiction, behavioral epidemiology and longitudinal data analysis and thus, is well poised to undertake the proposed research. The successful completion of this proposal will result in refined knowledge concerning the influence of HI and IN symptoms on substance use from adolescence to young adulthood. Such knowledge is necessary for effective preventive intervention planning and implementation.