Supplement to the Center for Culture, Trauma, and Mental Health Disparities

描述(由申请人提供)：我们正在申请补充资金，以对加州大学洛杉矶分校创伤和精神健康差异合作中心(MH07345)即将完成的5项研究收集和整合的数据进行二次分析。分析将基于对598名非洲裔美国人和拉丁裔男性和女性的与心理健康相关的心理社会因素和相关的生物健康风险指数的全面评估。使用一套复杂的二次数据分析技术，我们将描述心理健康结果，因为它们是通过一组生命过程中的风险和资源的综合指数来预测的，这些综合指数可能会提高高危个人的韧性和/或脆弱性。这些领域包括：(1)儿童和成年期急性创伤和慢性心理社会逆境的累积心理社会负担，(2)预计因童年和成年期创伤和逆境的累积负担而产生的生物健康风险指标(BHRI)的累积负担，以及(3)可调节非洲裔美国人和拉美裔美国人累积心理社会负担、累积BHRI负担和综合心理健康状况指数(即抑郁/创伤后应激障碍)之间关系的拟议保护资源(即族裔认同、宗教幸福感)。将对598名成年非洲裔和拉丁裔男性和女性进行分析，其中包括228名非洲裔美国人(63名女性，165名男性)和370名拉丁裔美国人(220名女性，150名男性)。数据是使用装有音频计算机辅助自访(ACASI)系统的笔记本电脑收集的，并辅之以面对面的私下采访。单变量和多变量统计方法将被用来开发预测因素、调节因素和心理健康结果，并在这个高风险和研究不足的样本中测试一个假设的心理健康状况预测模型。这一全面的生命历程方法提供了一个独特的机会，可以确定随着时间的推移导致精神健康差距的多个累积因素。 公共卫生相关性：我们预计，我们的结果将为使用风险和韧性综合指数估计心理健康结果风险的价值提供信息，在预测这些结果时确定脆弱性和韧性因素的潜在种族和性别差异，并确定未来干预研究的可能目标，以减少种族/民族心理健康差异。

DESCRIPTION (provided by applicant): We are requesting supplemental funding to conduct secondary analyses of data collected and integrated from 5 studies nearing completion in the Collaborative Center for Trauma and Mental Health Disparities at UCLA (MH07345). Analyses will be based on comprehensive assessments of psychosocial factors relevant for mental health and related biological health risk indexes from 598 African American and Latino men and women. Using a sophisticated set of secondary data analytic techniques, we will describe mental health outcomes as they are predicted by a set of composite indexes of risks and resources over the life-course that may promote resilience and/or vulnerabilities in individuals at high risk. Domains include: (1) cumulative psychosocial burden of acute trauma and chronic psychosocial adversities in childhood and adulthood, (2) the cumulative burden of biological health risk indicators (BHRI) of allostatic load that are predicted to result from cumulative childhood and adulthood burdens of trauma and adversities, and (3) proposed protective resources (i.e. ethnic identify, religious well-being) that may moderate the relationships between cumulative psychosocial burden, cumulative BHRI burden and a composite mental health status index (i.e. depression/PTSD) in African Americans and Latinos. Analyses will be conducted on a sample of 598 adult African American and Latino men and women, including 228 African Americans (63 women, 165 men) and 370 Latinos (220 women, 150 men). Data were collected using laptops equipped with the Audio Computer-Assisted Self-Interview (ACASI) system augmented by private face to face interviews. Univariate and multivariate statistical methods will be used to develop predictor, moderator and mental health outcomes and to test a hypothesized predictive model of mental health status in this high-risk and understudied sample. This comprehensive, life-course approach offers a unique opportunity to identify multiple cumulative contributors to mental health disparities over time. PUBLIC HEALTH RELEVANCE: We expect that our results will inform the value of using composite indexes of risk and resilience in estimating risk for mental health outcomes, identify potential ethnic and gender differences in vulnerability and resilience factors in predicting these outcomes, and identify possible targets for future intervention research to reduce racial/ethnic mental health disparities.