Multidisciplinary Subspecialty Pathology Research Fellowship Program

描述（由申请人提供）：在后基因组时代，生物医学数据的急剧扩展，包括人类在内的各种生物，揭示了生物系统的巨大复杂性，增加了我们对许多疾病过程的认识。这在肿瘤疾病方面尤其明显，基因组、表观基因组、转录组和蛋白质组的分子技术已经揭示了独特的分子途径及其网络，为治疗策略和临床结果提供了重要信息。这反过来又影响了包括病理学在内的许多医学学科的实践标准。癌症医学中新发展的个性化和靶向治疗概念增加并改变了病理学作为一门临床学科的传统角色。随着肿瘤分子检测的不断扩大和技术手段的复杂化，需要对传统的显微病理服务进行重新设计。该T32提案旨在通过实验室研究培训为培养新一代病理学家提供资源，以补充德克萨斯大学MD安德森癌症中心病理科现有的研究生医学教育认证委员会认可的临床奖学金项目。该计划的目标是培养下一代能够将诊断病理学的传统作用与调查分子方法相结合的医生/科学家病理学家。为了实现这一目标，一个为期两年的重点研究项目将把学员与经验丰富的教育工作者配对，他们也是有成就的翻译研究人员。学员将在导师的实验室工作，学习当今转化研究所需的实验室方法、流程和团队导向。本课程的毕业生将完成旨在通过以患者为导向的个性化治疗改善患者护理的研究项目，最后向同行评审的期刊提交一份手稿。在德克萨斯大学MD安德森癌症中心的课程作业和广泛的教育机会将补充实验室研究培训。结合亚专科临床培训，该项目将培养出非常优秀的学术、研究型病理学家，他们可以自己成为独立的研究人员和未来的学术导师。

DESCRIPTION (provided by applicant): Dramatic expansion of biomedical data in the post-genomic era on various organisms, including humans, has disclosed the enormous complexity of biological systems and increased our knowledge of many disease processes. This is particularly evident in reference to neoplastic disorders where molecular technologies on a genome, epigenome, transcriptome and proteomic scale have disclosed unique molecular pathways and their networks that provide significant information concerning therapeutic strategies and clinical outcomes. This in turn has affected the standard of practice of many medical disciplines including pathology. The newly developed concept of personalized and targeted therapies in cancer medicine increased and changed the traditional roles of pathology as a clinical discipline. The expanding molecular testing of tumors, with complex technologic approaches, requires a redesign of the conventional microscopic pathology services. This T32 proposal is intended to provide resources to train a new generation of pathologists via laboratory-based research training that will complement the current Accreditation Council for Graduate Medical Education-accredited clinical fellowship programs of the Department of Pathology at The University of Texas MD Anderson Cancer Center. The goal of this program is to train the next generation of physician/scientist pathologists capable of combining the conventional role of diagnostic pathology with investigative molecular approaches. To accomplish this goal, a focused 2-year research program will pair trainees with experienced educators who are also accomplished translational researchers. The trainees will work in their mentors' laboratories training in laboratory methods, processes, and team orientation needed in today's translational research. The graduates of this program will complete research projects aimed at improving patient care with patient-directed personalized treatment, concluding with the submission of a manuscript to a peer-reviewed journal. Coursework and a wide range of educational opportunities at The University of Texas MD Anderson Cancer Center will complement the laboratory research training. Combined with subspecialty clinical training, this program will produce extremely well-qualified academic, research-oriented pathologists who can, by themselves, be independent researchers and future academic mentors.