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TCDD Induced Developmental Effects

TCDD Induced Developmental Effects
TCDD 诱发的发育效应
批准号:
8535330
负责人:
KELLY INMAN
金额:
$22.24万
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-09-30 至 2013-09-29

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中文摘要
翻译
本研究的目的是检测发育中暴露于TCDD后基因表达的变化和成人子宫反应性的变化。这项研究将探讨雌性小鼠在GD15、哺乳期和/或4周时对TCDD的发育暴露的影响,以及成年动物对雌二醇和/或雌二醇+孕酮治疗的子宫反应。
英文摘要
The purpose of the study is to examine changes in gene expression and alteration in adult uterine responsiveness in response to developmental exposure to TCDD. The study will address the effects of developmental exposure of female mice to TCDD at GD15, lactation and/or 4 weeks, uterine responsiveness to estradiol and/or estradiol+progesterone treatment as adult animals.
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