Cancer Center Support Grant

项目总结(见说明)： 伯纳姆研究所癌症中心自1981年以来一直是癌症中心支持补助金的接受者，该中心占该研究所位于加利福尼亚州拉霍亚的预算和人员的近90%。癌症中心的使命是开展前沿的、协作性的基础研究，旨在了解人类癌症的发病机制，并促进基础研究成果的进展 转变为癌症预防、诊断和治疗的新策略。 自上次更新以来，伯纳姆癌症中心一直保持着强劲的发展势头。伯纳姆目前在全国所有研究机构中排名第四，在以每份出版物的引文量衡量其科学影响的全球前20个组织中排名第四。自上次续订以来，癌症中心已经出版了1500种出版物，其中20%是合作出版的。癌症中心有更多的 提高了其在细胞黏附、糖生物学、癌症遗传学、细胞信号和细胞死亡研究领域的科学地位。新兴的优秀领域包括肿瘤发展中的血管生物学和干细胞/祖细胞生物学。化学生物学的一个重要主题在我们的基础癌症研究和用于癌症治疗的分子探针和铅分子的开发之间建立了重要的联系。自上次续签以来，已招聘了21名新教师，使 正式会员人数增至56人(增加27%)。我们的赠款基数增加了60%，从5100万美元增加到8200万美元，合作赠款占我们NIH所有赠款资金的约55%，而2003年这一比例为25%。总体而言，癌症中心44%的拨款来自NCI和其他癌症机构。 通过深入的规划和评估过程，癌症中心现在已经修订了计划 它由四个高度协作和跨学科的项目组成，分别是肿瘤微环境、肿瘤发展、信号转导和凋亡与细胞死亡研究。这些计划得到了由9个共享资源组成的底层基础设施的支持。我们增强的化学生物学基础设施不仅帮助我们自己的科学家完成任务，而且还成为 由NIH和NCI的几笔赠款和合同支持的全国范围的资源。展望未来，我们在本申请中描述的计划寻求进一步提高我们在高影响力基础癌症生物学领域的声誉，并利用我们的化学生物学倡议来加强我们的基础癌症研究与我们希望在未来的癌症预防、诊断和治疗方面取得越来越大进展的愿望之间的联系。

PROJECT SUMMARY (See instructions): Burnham Institute's Cancer Center, which constitutes nearly 90% of the Institute's budget and personnel in La Jolla, CA, has been a recipient of the Cancer Center Support Grant continuously since 1981. The mission of the Cancer Center is to perform cutting-edge, collaborative basic research aimed towards understanding the pathogenesis of human cancer, and to promote the movement of basic research findings into novel strategies for cancer prevention, diagnosis, and therapy. Burnham's Cancer Center has continued on a strong trajectory since the last renewal. Burnham currently ranks 4th in NIH funding among all research institutes in the nation, and among top 20 organizations worldwide for its scientific impact measured by citations per publications. The Cancer Center has published >1,500 publications since the last renewal, of which 20% were collaborative. The Cancer Center has further enhanced its scientific prominence in the areas of cell adhesion, glycobiology, cancer genetics, cell signaling, and cell death research. Emerging areas of excellence include vascular biology and stem/progenitor cell biology in tumor development. An overarching theme of Chemical Biology has forged significant connections between our basic cancer research and the development of molecular probes and lead molecules for cancer therapy. 21 new faculty have been recruited since last renewal, bringing the number of full members to 56 (27% increase). Our grant base has increased by 60%, from $51 MM to $82MM, and collaborative grants constitute ~55% of all our NIH grant funding today, compared to 25% in 2003. Altogether, 44% of the Cancer Center's grants come from NCI and other cancer agencies. Through an in-depth planning and evaluation process, the Cancer Center has now a revised program structure, and consists of four highly collaborative and interdisciplinary Programs, named Tumor Microenvironment, Tumor Development, Signal Transduction, and Apoptosis & Cell Death Research. The Programs are buoyed by an underlying infrastructure that consists of 9 Shared Resources. Our enhanced Chemical Biology infrastructure not only aids the mission of our own scientists, but has also become a nation-wide resource supported by several grants and contracts from NIH and NCI. Going forward, our plans described in this application seek to further enhance our reputation in high-impact basic cancer biology, and to leverage our Chemical Biology Initiative to strengthen the linkage between our basic cancer research and our desire to make an increasingly substantial mark on the prevention, diagnosis, and treatment of cancer in the future.