Translational Research

翻译研究共享资源 自翻译研究共享资源(前身为病理学核心)成立以来，其使命一直是为KCC研究人员正在使用的人类肿瘤组织和实验动物模型组织提供组织处理、切片准备、组织化学染色和免疫组织化学染色。这一共享资源还提供了人类肿瘤组织的采购、储存和分配，以促进转译研究。最近成立的caBIG诊所 数据库提供与资源肿瘤/组织库中存在的组织样本相对应的病理和临床信息。此外，转化研究共享资源提供使用标准和CEMA技术的组织微阵列，以及来自资源肿瘤/组织库的石蜡档案材料。用于分子分析的不同细胞和组织类型的激光显微切割可以在资源的激光显微切割系统上执行。提供的所有功能 翻译研究共享资源，工作人员可为KCC调查人员提供技术支持和病理学专业知识。2006年，来自KCC不同项目的29名首席研究人员受益于这一共享资源，这些项目包括癌细胞生物学与信号学、分子生物学与遗传学、癌症中的免疫学机制、内分泌机制与激素作用、放射研究与翻译生物学以及胃肠癌。

TRANSLATIONAL RESEARCH SHARED RESOURCE Since the inception of the Translational Research Shared Resource (formerly the "Pathology Core") its mission has been to provide tissue processing, slide preparation, histochemical staining and immunohistochemical staining for human neoplastic tissue and experimental animal model tissue being utilized by KCC researchers. This shared resource has also provided procurement, banking and distribution of human neoplastic tissue in order to facilitate translational research. The recently instituted caBIG clinical data base provides pathologic and clinical information corresponding to the tissue specimens present in the resource tumor/tissue bank. In addition, the Translational Research Shared Resource provides tissue microarrays using standard and CEMA technology with paraffin archive material from the resource tumor/tissue bank. Laser microdissection of distinct cell and tissue types for molecular analysis can be performed on the resource's Laser Microdissection system. For all of the capabilities offered by the Translational Research Shared Resource, staff is available to provide technical support and pathology expertise to KCC investigators. In 2006 twenty nine principal investigators from various programs of KCC including Cancer Cell Biology & Signaling, Molecular Biology & Genetics, Immunological Mechanisms in Cancer, Endocrine Mechanisms & Hormone Action in Cancer, Radiation Research & Translational Biology and Gastrointestinal Cancer benefited from this shared resource.