FASEB Summer Research Conference: Phospholipid Metabolism: Disease, Signal Transd

描述（由申请人提供）：申请资金支持2012年（7月15-20日，佛蒙特学院），2014年和2016年FASEB夏季研究会议，题为：磷脂代谢：疾病，信号转导和膜生物物理学。该学科领域得到了美国国立卫生研究院的大力支持，有近500个活跃项目由美国国立卫生研究院提供的资金支持，在过去十年中每年产生约5000篇同行评议的研究出版物。这是一个正在进行的会议，于1988年首次作为“磷脂酶”会议提出。会议与最初的内容相比有了很大的变化，现在涵盖了与磷脂代谢、磷脂信号传导和膜生物物理学相关的大多数主要学科。此外，由于该领域的研究日益多学科化，该会议已与一般生物医学研究界的成员更加相关。在很大程度上，这是由代谢磷脂的酶的分子和药理学工具的可用性以及缺乏这些酶的敲除小鼠的可用性所驱动的。这使得其他领域的研究人员可以研究磷脂在特定细胞功能以及生理和病理生理过程中的作用。会议强调了这些领域的进展，也关注了脂质/蛋白质运输、核脂质信号传导和氧化磷脂，这些学科在过去并不是主要的焦点。重点的转变不仅强调了组织者的研究兴趣，而且也是有意扩大会议的重点，吸引可能不会参加会议的新研究人员。会议分为八个主题，其中30分钟的演讲由该领域的领导者邀请，15分钟的演讲将从提交的摘要中选择。包括两次海报会议，以及由脂质组学/脂质谱组核心主任领导的脂质组学/脂质谱“最新技术”的非正式讨论。组织者将邀请年轻的调查人员进行15分钟的演讲，并将利用这些时间招募更多的女性演讲者和来自代表性不足群体的演讲者。该提案的资金将用于为这些个人提供旅行奖励，并使他们能够带他们实验室的成员参加会议。

DESCRIPTION (provided by applicant): Funds are requested to support for the 2012 (July 15-20, Vermont Academy), 2014, and 2016 offerings of the FASEB Summer Research Conference entitled: Phospholipid Metabolism: Disease, Signal Transduction, and Membrane Biophysics. The subject area receives considerable support from the NIH with nearly 500 active projects sustained by funds provided by NIH institutes and has generated ~5000 peer reviewed research publications each year in the past decade. This is an on-going conference that was first offered as a "phospholipases" meeting in 1988. The conference has changed substantially from its original offering and now encompasses most of the major disciplines related to phospholipid metabolism, phospholipid signaling, and membrane biophysics. Furthermore, the conference has become more relevant to members of the general biomedical research community, as research in the field had become increasingly multidisciplinary. In large part, this has been driven by the availability of molecular and pharmacological tools for enzymes that metabolize phospholipids and by availability of knockout mice lacking these enzymes. This has allowed researchers in other areas to investigate the involvement of phospholipids in specific cellular functions as well as physiological and pathophysiological processes. The meeting highlights advances in these areas and also focuses on lipid/ protein trafficking, nuclear lipid signaling, and oxidized phospholipids, disciplines that have not been major foci in the past. The shift in emphasis not only underscores the research interests of the organizers, but is also a deliberate attempt to broaden the focus of the meeting to engage new researchers who might not otherwise attend the conference. The meeting is organized into eight themes, which feature 30- minute talks by invited speakers who are leaders in the field and 15-minutes talks to be chosen from among submitted abstracts. Two poster sessions are included as well as an informal discussion of the "state of the art" of lipidomics/ lipid mass spectrometry led by Core Directors i the LIPID MAPS group. The Organizers will invite young investigators to present the 15-minute talks and will use these slots to recruit additional female speakers and speakers from underrepresented groups. Funds from this proposal will be used to provide travel awards for such individuals and also to enable them to bring members of their laboratories to the conference. PUBLIC HEALTH RELEVANCE: Funds are requested to support for the 2012 (July 15-20, Vermont Academy), 2014, and 2016 offerings of the FASEB Summer Research Conference entitled: Phospholipid Metabolism: Disease, Signal Transduction, and Membrane Biophysics. This is a broad subject area that encompasses both basic and translational science that underscores atherosclerosis, diabetes, inflammation, cancer, and other diseases. The funds will primarily be used to enable young investigators to attend the meeting as involvement of such individuals is essential to ensure that our discipline continues to evolve to meeting the health care needs of the 21st century.