Phenotyping Core

表型核心将为ORDRCC研究人员提供先进的高含量、尖端的生物分子表型服务和数据集，涵盖临床样品的遗传、基因组、蛋白质组学和功能性细胞生物反应，这些数据集可通过临床表征和生物存储核心（CCBC）或其他ORDRCC研究者项目获得。ORDRCC内表型核心和CCBC的紧密集成，既可以有效地进行表型表征，也可以将临床特征与特定临床样本的分子或细胞表型相关联。将分子或细胞表型完整表征所需的一系列技术整合到一个Core中，使Core能够更好地协助所有ORDRCC研究人员根据其个人项目需求进行有效的规划/设计，执行和数据分析。核心能够提供使用临床标本进行研究的经验，在广泛的分子和生物测定中必要的技术专长，获得设备和资源，使尖端方法能够解决研究问题，收集数据的质量控制评估和数据处理适合于表型/临床关联的高端统计建模。因此，表型核心的目标可以概括如下：

The Phenotyping Core will provide ORDRCC investigators with access to advanced high-content, cutting-edge biomolecular phenotyping services and datasets spanning genetic, genomic, proteomic, and functional cellular bioresponses on clinical samples available through the Clinical Characterization and Biorepository Core (CCBC) or from other ORDRCC Investigator projects. The tight integration of the Phenotyping Core and the CCBC within the ORDRCC enables both the efficient performance of phenotype characterizations and correlation of the clinical characteristics with molecular or cellular phenotypes on specific clinical samples. Consolidation of the range of technologies required for the complete characterization of a molecular or cellular phenotype into a single Core allows the Core to better assist all ORDRCC investigators in the efficient planning/design, execution and data analysis as dictated by their individual project needs. The Core is able to provide experience in performing research using clinical specimens, the necessary technical expertise in a wide range of molecular and bioassays, access to equipment and resources enabling cutting-edge approaches to address research questions, quality control assessment of the data collected and data processing suitable for higher end statistical modeling of phenotype/clinical associations. Therefore, the goals of the Phenotyping Core can be summarized as follows: Goal 1: Offer expert consulting for experimental project design, cost analysis, implementation planning and project management for ORDRCC investigators. Goal 2: Provide access to advanced technology, centralized equipment and experienced personnel for high throughput/high content experimental phenotype characterization and biomarker assays in genetic, genomic, proteomic, immune phenotype and immune functional domains. Goal 3: Supply guidance on data quality control, processing of raw data, and preparation of data sets for more extensive statistical modeling. Goal 4: Assess and develop new cutting edge technologies for phenotype characterization.