Patients, Clincs, and Systems: Screening for Alcohol Use

以患者为中心的研究中的职业生涯中期研究人员奖的修订后的竞争更新是 提交这份文件是为了使我能够巩固和推广第一个奖项所取得的成就。AS 应审查委员会的要求，关于我的指导理念和指导对象的更多信息如下 包括在内。续约将支持我的目标，为以患者为导向的酒精做出重大贡献 特别注重妇女健康的研究，并继续作为下一代的教师 临床研究人员。在指导方面，我想继续我原本没有资金的个人指导 活动，同时还领导医院范围内跨学科指导计划的发展，作为 我是临床研究中心(CCI)的核心组成部分，在那里我是教育主任。在病人中- 以研究为导向，我提出的项目，《酒精和物质使用的鉴定和修改》 怀孕的青少年“不仅将综合先前临床研究的几个卓有成效的系列 识别和减少孕期饮酒风险，并在减少饮酒风险方面采取激励性干预措施 青少年药物使用，但也解决了一个特别脆弱群体的需求。最新进展 试点研究和最终的临床试验将为初级研究人员提供充足的机会 参与进来。美国的青少年怀孕率是发达国家中最高的， 每年大约有100万青少年怀孕。这些青少年怀孕中的大多数是 没有计划的，而且往往在成年怀孕后才被发现。青少年的健康危险行为 由于物质使用和性行为聚集在一起，构成了年轻人固有的生物风险 产妇年龄和青少年怀孕的不良社会后果。该研究的目的是 两个方面：1)评估CRAFFT酒精和药物使用筛查仪在怀孕青少年中的应用，以及 2)检验这样的假设，即那些接受动机干预的受试者将表现出更大的 酒精和物质使用的减少比随机进入注意力控制条件的减少，包括 进行产前营养教育。拟议的研究地点是青年生殖健康服务，Run 在过去的二十年里，布里格姆妇女医院与儿童医院合作， 每年为200名新患者提供服务。

This revised Competitive Renewal for the Midcareer Investigator Award in Patient-Oriented Research is being submitted to allow me to consolidate and extend the achievements realized with the first award. As requested by the Review Committee, more information about my mentoring philosophy and mentees is included. A renewal would support my goals to make a significant contribution to patient-oriented alcohol research with a particular focus on women's health, and to continue as a teacher of the next generation of clinical researchers. In mentoring, I would like to continue my otherwise unfunded individual mentoring activities, while also leading the development of a hospital-wide, interdisciplinary mentoring program as a core component of the Center for Clinical Investigation (CCI), where I am Director of Education. In patient- oriented research, my proposed project, "Identification and Modification of Alcohol and Substance Use by Pregnant Adolescents," will not only synthesize several fruitful lines of previous clinical research in the identification and reduction of risk drinking in pregnancy, and motivational interventions in reducing adolescent substance use, but also address the needs of a particularly vulnerable group. The development of a pilot study and eventual clinical trial will provide ample opportunities for junior investigators to participate. The rate of adolescent pregnancy in America is the highest among developed nations, with approximately 1 million teenagers becoming pregnant every year. Most of these adolescent pregnancies are unplanned, and tend to be recognized later than adult pregnancies. Adolescent health risk behaviors such as substance use and sexual activity cluster together, componding the biologic risk inherent in young maternal age and the adverse social consequences of adolescent pregnancy. The study's purpose is twofold: 1) to evaluate the CRAFFT alcohol and drug use screening instrument in pregnant adolescents, and 2) to test the hypothesis that those subjects receiving the motivational intervention will demonstrate greater reductions in alcohol and substance use than those randomized to the attention control condition, consisting of prenatal nutrition education. The proposed study site is the Young Adult Reproductive Health Service, run by the Brigham and Women's Hospital in conjunction with Children's Hospital for the past two decades, and serves 200 new patients annually.