Research Training in Pediatric Critical Care Medicine

描述(由申请人提供)：显然需要增加儿科重症监护医学方面的学术内科-科学家，并合作对新的治疗模式进行严格的调查，重点是病理生物学和长期发病率。本次续签申请要求提供资源，以继续我们在加州大学旧金山分校儿科内科开展的为期四年的儿科重症监护医学博士后研究培训计划。应用程序的目标是增加训练有素、成功资助和可持续发展的儿科重症监护内科医生-科学家的数量，他们将 进行高水平的实验室和/或临床转化研究，最终将提高我们对危重疾病的病理生物学的了解，改善短期和长期结果，并降低残障儿童和/或慢性病儿童的发病率。为此，该计划旨在为拥有医学博士或医学博士/博士学位的儿科医生提供全面的科学培训和职业发展指导，这些医生致力于具有强大研究成分的学术事业。培训计划的关键要素是(1)指导研究经验，(2)科学课程工作，(3)职业发展研讨会，(4)跨学科经验，(5)持续审查和评估。该计划的核心是继续为期4年的奖学金培训计划，其中两年致力于基础实验室科学、临床-翻译科学或与儿科危重疾病相关的流行病学方面的强化研究培训。大量非常合格的教职员工承诺为拟议的培训补助金支持的研究员提供指导。这些教员隶属于加州大学旧金山分校的几个校区，并组织了研究单位和项目，其中包括心血管研究所、流行病学和生物统计学系、生物医学科学项目、生物科学项目、几个加州大学旧金山分校临床校区和奥克兰儿童医院。所有研究员将参加(1)负责任的研究行为、(2)科学写作和(3)讲课艺术的课程。学员指导计划将支持博士后研究员的培训和职业发展。研究员将在参加培训时与三名教师导师配对；导师将定期与研究员会面，以帮助他/她制定和监督培训和职业目标。重症护理医学司在招募和培训儿科分科专家方面有着良好的记录。在完成培训计划的5名学员中，有3人已经获得了NIH K奖(K奖的获得率为60%)，其余两人中的一人将在6月份提交K奖。这5所大学都有学术教授的任命。因此，这一更新的理由是基于对精心设计的培训计划的充分证明的需求，以使儿科科学家为在儿科重症监护研究中持续富有成效的职业生涯做好准备，以及加州大学旧金山分校拥有培养下一代儿科科学领导者的远见、经验和基础设施。 公共卫生相关性：显然需要增加儿科重症监护医学领域的学术内科科学家，并合作对新的治疗方式进行严格调查，重点放在病理生物学和长期发病率上。该应用程序的目标是增加训练有素、成功资助和可持续发展的儿科重症监护医生/科学家的数量，他们将进行高水平的实验室和/或临床转化研究，最终将提高我们对危重疾病病理生物学的理解，改善短期和长期结果，并降低残留残疾和/或慢性病儿童的发生率。

DESCRIPTION (provided by applicant): The need for increased academic physician-scientists in Pediatric Critical Care Medicine, and collaborative rigorous investigation of new treatment modalities with focus on pathobiology and long-term morbidities is clear. This renewal application requests the resources to continue our four-year post-doctoral research training program in Pediatric Critical Care Medicine within the Department of Pediatrics at the University of California, San Francisco. The goal of the application is to increase the number of highly trained, successfully funded and sustainable pediatric critical care physician-scientists, who will perform high level laboratory and/or clinical- translational research that will ultimately improve our understanding of the pathobiology of critical illness, improve short and long-term outcomes, and reduce the incidence of children with residual disabilities and/or chronic disease. To this end, this program aims to provide comprehensive science training and mentoring career development for pediatricians with an M.D. or M.D. /Ph.D. degree who commit themselves to an academic career with a strong research component. The key elements of the training program are (1) a mentored research experience, (2) scientific course work, (3) career development workshops, (4) interdisciplinary experiences, (5) continuing review and evaluation. The centerpiece of the program is the continuation of a 4-year fellowship training program, with two years devoted to intense research training in basic laboratory science, clinical-translational science, or epidemiology related to pediatric critical care disease. A large number of exceptionally qualified faculty has committed their support as mentors for fellows supported by the proposed training grant. These faculty are affiliated with several of the UCSF campuses and organized research units and programs, which include the Cardiovascular Research Institute, the Department of Epidemiology and Biostatistics, the Biomedical Science Program, the Program in Biological Sciences, several UCSF clinical campuses, and Oakland Children's Hospital. All fellows will take courses in (1) Responsible conduct in research, (2) Scientific writing and (3) The art of lecturing. A Trainees Mentoring Program will support post-doctoral fellows in their training and career development. Fellows will be matched with three faculty mentors on entry into their training; the mentors will meet with the fellow on a regular basis, to assist him/her in setting and monitoring training and career goals. The Division of Critical Care Medicine has a strong track record in recruiting and training pediatric sub-specialists. Of the 5 trainees who have completed the training program, three have already been awarded NIH K awards (60% rate of K awards), and one of the remaining two is submitting a K award in June. All 5 have academic faculty appointments. Thus, the rationale for this renewal is based on the well-documented need for well-designed training programs to prepare pediatric-scientists for a sustained productive career in Pediatric Critical Care research and the fact that UCSF has the vision, experience and infrastructure to train the next generation of leaders in pediatric science. PUBLIC HEALTH RELEVANCE: The need for increased academic physician-scientists in Pediatric Critical Care Medicine, and collaborative rigorous investigation of new treatment modalities with focus on pathobiology and long-term morbidities is clear. The goal of the application is to increase the number of highly trained, successfully funded and sustainable pediatric critical care physician-scientists, who will perform high level laboratory and/or clinica- translational research that will ultimately improve our understanding of the pathobiology of critical illness, improve short and long-term outcomes, and reduce the incidence of children with residual disabilities and/or chronic disease.