CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCH

该子项目是对CTSA供资的百分比的估计， 用于广泛的研究领域（艾滋病研究，儿科研究，或 临床试验）。 列出的总成本仅为CTSA金额的估算 基础设施走向这一领域的研究，而不是直接提供资金， 向子项目或子项目工作人员提供NCRR补助金。 匹兹堡大学是唯一适合，致力于和有义务改变其学术文化，环境和结构，以进一步促进临床和转化科学作为一个独特的学科在当地和全国。该大学的临床和转化科学研究所（CTSI）成立于2006年，旨在领导一项前所未有的机构间倡议，以实现这一目标。在过去的四年中，CTSI彻底改变了大学的研究企业，以开发，培养和支持训练有素的临床和转化科学家的新干部，并使他们的创新研究。通过对前CTSA计划的新机构整合以及新的跨学科研究和培训计划的发展，CTSI使我们的科学家能够在产生新的生物医学知识和在整个翻译研究领域双向翻译这些知识方面表现出色。我们对CTSI的系统方法基于渐进式转型过程，该过程不断评估计划成果，以过去和当前的活动为基础，创建新的计划并修改现有计划，并指导CTSI总体目标的演变。这种动态的方法导致在十个CTSI核心中开发了无数的基础设施、程序和服务。它也是管理CTSI下一个发展阶段的基础。在未来五年，我们将：1）通过整合协作方法来整合临床和转化研究和教育计划，2）通过基于能力的教育计划和将指导注入各级培训来改造我们的科学家，以通过下一代推进临床和转化科学领域，3）通过提供一个强大的资源环境来支持团队科学，并通过开发数据共享机制来改变研究，以及4）通过允许双向研究翻译的全面参与性伙伴关系来改变卫生实践和社区。这些转变将导致匹兹堡大学发生根本性的变化，使CTSI的教师和研究人员能够进行有远见的，相关的临床和转化研究。 公共卫生相关性（由申请人提供）：通过建立临床和转化科学作为一个独特的学科，CTSI的重点是将可操作的研究成果转化为实践和预防环境，改善个人和人群的健康水平。CTSI的推广使用基于社区的参与性研究模式，使公民能够与CTSI合作，以确定和解决自己的医疗保健需求，使用健全的公共卫生原则。

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): The University of Pittsburgh is uniquely suited, committed, and obligated to transform its academic culture, environment, and structure to further promote clinical and translational science as a distinct discipline locally and nationally. The University's Clinical and Translational Science Institute (CTSI) was founded in 2006 to lead an unprecedented inter-institutional initiative to achieve this goal. Over the past four years, CTSI revolutionized the University's research enterprise to develop, nurture, and support a new cadre of highly trained clinical and translational scientists and to enable their innovative research. Through novel institutional integration of pre-CTSA programs and the development of new interdisciplinary research and training initiatives, CTSI enabled our scientists to excel in generating new biomedical knowledge and translating this knowledge bidirectionally across the entire translational research spectrum. Our systematic approach to CTSI is based on an evolutionary transformation process that continuously evaluates programmatic outcomes, builds on past and current activities to create new and modify existing plans, and guides the evolution of CTSI's overarching goals. This dynamic approach resulted in the development of myriad infrastructure, programs, and services in ten CTSI Cores. It also serves as the basis for managing CTSI's next period of evolutionary growth. Over the next five years, we will: 1) transform our institution through an integrative collaborative approach to coalesce clinical and translational research and education programs, 2) transform our scientists through competency-based educational programs and the infusion of mentoring into all levels of training to advance the field of clinical and translational science through the next generation, 3) transform research by providing a robust resource environment to support team science and through the development of mechanisms for data sharing, and 4) transform health practice and the community through participatory partnerships that permit the full scope of bi-directional research translation. These transformations will lead to fundamental changes at the University of Pittsburgh that will enable CTSI faculty and investigators to conduct visionary, relevant clinical and translational research. PUBLIC HEALTH RELEVANCE (provided by applicant): By establishing clinical and translational science as a distinct discipline, CTSI's focus is on moving actionable research findings into practice and prevention settings, improving health at the individual and population levels. CTSI's outreach using a community based participatory research model enables citizens to partner with CTSI to identify and address their own health care needs using sound public health principles.