University of Pittsburgh Clinical and Translational Science Institute

匹兹堡大学临床与转化科学研究所

• 批准号: 10599474
• 负责人: STEVEN E REIS
• 金额: $ 15.34万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-12 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10599474
• 关键词: Caring; Clinical Sciences; Communities; Discipline; Dissemination and Implementation; Healthcare Systems; Individual; Infrastructure; Institutes; Mission; National Center for Advancing Translational Sciences; Participant; Patients; Pennsylvania; Positioning Attribute; Process; Provider; Quality Control; Registries; Research; Research Design; Resources; Scientist; Speed; System; TNFSF15 gene; Training; Translational Research; Translations; Universities; Work; community engagement; design; health practice; human subject; programs; quality assurance; workforce needs

Project Summary/Abstract Since 2006, the Clinical and Translational Science Institute (CTSI) has fundamentally transformed the University of Pittsburgh (Pitt) and its approach to training scientists (2,419), its conduct of research (6,551 studies), and its community engagement (>200 community partners) and the integration of research in health practice across western Pennsylvania (>250K research participants in Pitt+Me Registry). We established clinical and translational science as a new academic discipline across Pitt and its affiliated healthcare system, UPMC, and created the infrastructure and workforce needed to sustain it. We are now poised to pivot from successfully enabling the sequential translation of individual studies to systematically accelerating the real- world impact of research. We define “research impact” as changing standards of care through the dissemination and sustained implementation of best practices supported by translational research evidence. Over the next 5 years, we will provide the training, resources, and expertise necessary for CTSI-supported studies to develop a “path to impact” and thus support progress toward achieving our mission: CTSI will accelerate the dissemination and implementation, and hence the impact, of translational research. Each CTSI program has new activities specifically designed to support specific steps on the path from idea to impact: Team Assembly, Study Design, Study Conduct, Dissemination & Implementation. We will create translational research teams who envision the impact of their work on the communities that they seek to benefit (patients, providers, policymakers, etc.) at each step of the research process, from conceptualizing questions through implementing findings. Every CTSI-supported study will be “designed for impact”. By adding a dedicated quality assurance/quality control position to our team to perform quality reviews of CTSA-related submissions to NCATS, submissions to the eRA Human Subjects System, and management of the overall process, we will increase the speed and efficiency of getting our pilot awardees, KL2 Scholars, and TL1 Fellows on the path to impact.

项目总结/摘要 自2006年以来，临床和转化科学研究所（CTSI）从根本上改变了 匹兹堡大学（皮特）及其培养科学家的方法（2，419）、其研究行为（6，551） 研究），其社区参与（>200个社区合作伙伴）和健康研究的整合 Pitt+Me Registry的研究参与者超过25万人。我们建立 临床和转化科学作为皮特及其附属医疗保健系统的一门新学科， UPMC，并创建了维持其所需的基础设施和劳动力。我们现在准备从 成功地使个别研究的顺序翻译系统地加速真实的- 研究的世界影响。我们将“研究影响”定义为通过以下方式改变护理标准： 传播和持续实施由转化研究证据支持的最佳做法。 在未来5年，我们将为CTSI支持的项目提供必要的培训、资源和专业知识。 研究开发“影响之路”，从而支持实现我们的使命：CTSI将 加快传播和实施，从而影响，转化研究。每个CTSI 该计划有专门设计的新活动，以支持从想法到影响的具体步骤： 团队组建、研究设计、研究实施、传播和实施。我们将创建一个 研究团队设想他们的工作对他们寻求受益的社区的影响（患者， 提供者、决策者等）在研究过程的每一步，从概念化问题， 执行调查结果。CTSI支持的每一项研究都将“为影响而设计”。通过添加专用的 我们团队的质量保证/质量控制职位，对CTSA相关提交文件进行质量审查 向NCATS提交，向eRA人类受试者系统提交，以及管理整个过程，我们将 提高速度和效率，让我们的飞行员获奖者，KL 2学者，和TL 1研究员的道路上， 冲击