University of Kansas Alzheimer's Disease Core Center

这是一份来自堪萨斯大学研究人员的阿尔茨海默病核心中心（ADCC）的申请。在过去的五年中，KU团队开发了托管ADCC所需的基础设施。纵向特征的阿尔茨海默病（AD）和年龄匹配的对照队列已经建立，这些队列支持了许多研究项目。我们的研究队列按照统一数据集（UDS）指南进行神经心理学特征描述，并在研究专用的神经成像中心进行神经成像。每一步都是在专家统计支助和数据库管理投入的情况下规划的。精心策划的外行人群和当地医疗保健专业人员的外展促进了受试者的招募，保留，并提高了我们在堪萨斯城（KC）都市区（美国第29大都市区）对AD研究计划的认识。

This Is an Alzheimer's Disease Core Center (ADCC) application from investigators at the University of Kansas (KU). Over the past five years the KU team has developed the infrastructure needed to host an ADCC. Longitudinally characterized Alzheimer's disease (AD) and age-matched control cohorts have been established and these cohorts have supported numerous research projects. Our research cohorts have been characterized neuropsychologically per Uniform Data Set (UDS) guidelines and neuroimaged at a research-dedicated neuroimaging Center. Every step has been planned in conjunction with expert statistical support and database management input. Carefully orchestrated outreach to the lay population and local healthcare professionals has facilitated subject recruitment, retention, and raised awareness of our AD research program throughout the Kansas City (KC) metro area, the 29th largest metro area in the USA. The KU ADCC consists of the five NIA-mandated ADCC cores, a Neuroimaging Core, and a Mitochondrial Genomics and Metabolism Core. This infrastructure helps us pursue our principal aim of effectively and comprehensively supporting AD and AD-related research at KU. To this end KU ADCC services have already invigorated KU's AD research portfolio and we currently maintain a diverse portfolio of supported research projects. A second aim of the KU ADCC is to provide advanced services that enable and facilitate ground-breaking AD, AD-related, and brain aging metabolism research. Our expertise and the highly integrated, Inter-disciplinary services we provide will help the AD research field define how fitness, metabolism, and mitochondria independently and collectively influence progression and outcome in AD. We are confident that incorporating our expertise within the ADC system will prove both practical and valuable, strengthen the existing ADC system, and advance the AD research field.