Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirth (PASS) Network

描述（由申请人提供）：PASS网络的目标是确定产前酒精暴露在婴儿猝死综合征（SIDS）和妊娠不良后果风险中的作用，特别是死胎和胎儿酒精谱系障碍（FASD），以及SIDS、死胎和FASD之间的潜在相互关系。本申请是对申请请求（RFA-HD-10-018）题为“产前酒精暴露在小岛屿发展中国家和死胎中的作用”的回应。根据要求，建议由目前的五个临床、生理、生物/病理和数据协调中心完成研究参与者的登记和随访，并在PASS网络的第二期进行数据分析。该网络的任务是开展与社区相关的研究，以调查产前酒精暴露在小岛屿发展中国家、死胎和FAS风险中的作用，并确定这些不同结果如何相互关联。PASS网络是由两个综合临床站点(CCS) -北部平原综合临床站点（NPCCS）和Stellenbosch综合临床站点（SCCS），一个发育生物学和病理学中心（DBPC），一个生理评估中心（PAC）和一个集中的数据协调和分析中心（DCAC）以及NICHD和NIAAA的项目科学家和官员组成的协作努力。这个特殊的应用程序属于PASS网络的生理评估中心（PAC）。PAC的作用是监督数据收集基础设施，并分析在PASS网络临床站点测试的12,000名受试者的生理数据。这些早期评估将在不良后果发生之前确定产前酒精和其他暴露的生理后果。这项工作的潜在影响是，结合病理、环境和遗传发现，我们将能够更好地确定死产SIDS和FASD易感性的机制。所获得的信息将为前瞻性地识别风险最大的胎儿和婴儿以及更精确地进行早期干预提供可能。

DESCRIPTION (provided by applicant): The goal of the PASS Network is to determine the role of prenatal alcohol exposure in the risk for the sudden infant death syndrome (SIDS) and adverse outcomes of pregnancy, particularly stillbirth and fetal alcohol spectrum disorders (FASD), and in the potential inter-relationships between SIDS, stillbirth, and FASD. This application is in response to the Request for Application (RFA-HD-10-018) entitled "Role of Prenatal Alcohol Exposure in SIDS and Stillbirth". As requested, it proposes the completion of enrollment and follow-up of study participants and the performance of data analysis in Phase II of the PASS Network by the current five clinical, physiologic, biologic/pathologic, and data coordinating centers. The mission of the network is to conduct community-linked studies to investigate the role of prenatal alcohol exposure in the risk for SIDS, stillbirth and FAS, and to determine how these different outcomes are inter-related. The PASS Network is a collaborative effort comprised of two Comprehensive Clinical Sites (CCS) - Northern Plains Comprehensive Clinical Site (NPCCS) and Stellenbosch Comprehensive Clinical Site (SCCS), a Developmental Biology and Pathology Center (DBPC), a Physiology Assessment Center (PAC), and a centralized Data Coordinating and Analysis Center (DCAC) and program scientists and officers at the NICHD and NIAAA. This particular application pertains to the Physiology Assessment Center (PAC) of the PASS Network. The role of the PAC is to oversee the data collection infrastructure and analyze the physiological data from the 12,000 subjects tested at the PASS Network Clinical Sites. These early assessments will define physiological consequences of prenatal alcohol and other exposures prior to the development of adverse outcomes. The potential impact of this work is that, in combination with pathological, environmental and genetic findings, we will be better able to define the mechanisms that underlie vulnerability to stillbirth SIDS and FASD. The information gained will provide the potential for prospectively identifying fetuses and infants at greatest risk and the possibility for more precise targeting of early interventions. PUBLIC LEALTH RELEVANCE: The PASS Network will perform community-linked studies to determine the role of prenatal alcohol exposure in the risk for SIDS and adverse pregnancy outcomes, especially stillbirth and FASD. The study hopes to decrease fetal and infant death and improve child health in communities at high risk for prenatal maternal alcohol consumption.