From pathogenesis to therapeutics: targeting two signalling pathways as a therapeutic strategy to treat preeclampsia

先兆子痫是一种严重的妊娠并发症，每年夺去数千名母亲和婴儿的生命。除了分娩和胎盘外，没有有效的药物治疗。我们缺乏治疗方法很大程度上是由于我们对这种疾病的了解不足。在这个应用程序中，我们计划彻底表征我们认为负责子痫前期的两条途径，有效地确定新疗法可以靶向的许多点。

Preeclampsia is a serious complication of pregnancy that claims the lives of thousands of mothers and babies each year. There is no efficacious medical treatment besides delivery of the baby and placenta. Our lack of therapeutics is largely a result of our poor understanding of the disease. In this application we plan to thoroughly characterise two pathways we believe responsible for preeclampsia, effectively identifying many points at which new therapies could be targeted.