Imaging

项目总结(见说明)： 拟议的项目是一项计划，将在加州大学旧金山分校的项目拨款中增加一个成像核心，标题为：额颞部痴呆：基因、图像和情绪。这一PPG的新核心是对日益复杂的成像和更多地使用成像来回答与FTD相关的问题的回应。自从这种PPG问世以来，脑成像技术的数量已经显著扩大。我们的团队 开始使用结构成像作为FTD解剖学评估的主要手段，并已转向采用扩散张量成像(DTI)、动脉自旋标记灌注(ASL)和固有连接功能磁共振(ICN FMRI)，以及FDG-PET和PIB-PET。下一个PPG周期的主要目标将是调查这些不同技术单独或联合用于诊断和描绘FTD中大脑行为关系的相对效用。许多核心和项目将利用这些不同类型的成像模式。虽然另外两个项目将研究复杂的多模式成像新分析方法(项目2)和ICN功能磁共振成像(项目6)，但这一成像核心将通过确保高质量图像的获取和存档、执行基本的预处理以及提供基本的成像数据和图像，促进这些项目和PPG的其余部分使用图像。具体地说，Core E将：1)收集和管理患有bvFTD、nfvPPA、svPPA、IVPPA、CBS、PSPS、ALS、以记忆为主的认知缺陷(MEM)、无症状FTLD导致突变的携带者(MUT)和对照组患者在3Tesla的以下MRI序列：MP-RAGE、FLAIR、T2加权、DTI、ASL灌注和ICN fMRI。我们还将获得[18FJFDG和[1 ICjPIB PET扫描，2)对MR图像进行预处理，包括射频场偏置和几何失真校正，并将所有图像与每个受试者的“自然空间”共同配准，3) 使用Freesurfer(FS)处理TL加权图像，得出FS空间中标准ROI的皮质厚度和体积、区域灌注、FDG代谢和归一化淀粉样示踪剂结合值；4)咨询PIS和其他PPG项目和岩心的工作人员，将成像数据纳入他们的分析。

PROJECT SUMMARY (See instructions): The proposed project is a plan to add an imaging core to the UCSF Program Project Grant, entitled: Frontotemporal Dementia: Genes, Images and Emotions. This new core for this PPG is a response to the increasing complexity of imaging and increased use of imaging to answer questions related to FTD. Since the inception of this PPG, the number of techniques for brain imaging has expanded significantly. Our group began using structural imaging as the mainstay for anatomical assessment of FTD, and has moved on to embrace diffusion tensor imaging (DTI), arterial spin labelled perfusion (ASL) and intrinsic connectivity functional MRI (ICN fMRI), as well as FDG-PET and PIB-PET. A major goal for the next cycle of the PPG will be to investigate the relative utility of these various techniques, alone or in combination, for diagnosis and for delineating brain-behavior relatioships in FTD. Many of the cores and projects will make use of these various types of imaging modalities. While two other projects will investigate sophisticated new anaytic approaches for multimodality imaging (Project 2) and ICN fMRI (Project 6), this imaging core will facilitate use of images by these projects and the rest of the PPG by ensuring acquistion and archiving of high quality images, performing basic pre-processing, and providing basic imaging data and images. Specifically, Core E will: 1) collect and manage the following MRI sequences at 3Tesla in patients with bvFTD, nfvPPA, svPPA, IvPPA, CBS, PSPS, ALS, memory-predominant cognitive deficits (MEM), asymptomatic carriers of FTLD-causing mutations (MUT) and controls: MP-RAGE, FLAIR, T2-weighted, DTI, ASL perfusion, and ICN fMRI. We will also acquire [18FJFDG and [1 ICjPIB PET scans, 2) preprocess MR images including RF field bias and geometrical distortion corrections and coregistration of all images to each subject's "native space", 3) process Tl-weighted images with FreeSurfer (FS) and derive cortical thickness and volumes, regional perfusion, FDG-metabolism, and normalized amyloid tracer binding values for standard ROIs in FS space, 4) consult with Pis and staff serving the other PPG projects and cores on incorporating imaging data into their analyses.