Aging Aminal & Longevity Assessment Core

老化动物和寿命评估核心的目的是为中心研究者和 研究人员在大学外的老化与广谱的统一维护，特定病原体免费 用于研究衰老的啮齿动物模型，根据需要。核心将继续发挥核心作用 内森·休克衰老中心核心中的所有动物都将得到NIA或其他老龄补助金的支持。的 核心将繁殖，维护和监测老化的啮齿动物群体，确定它们的寿命和年龄相关 体重、身体成分和食物摄入量的变化，并将这些动物分配给中心成员， 另一些则用于衰老的基础研究。此外，核心小组将为试点研究保留两个小群体， 中心的研究人员最近发现， 衰老的基本机制：1）雷帕霉素处理的遗传异质性小鼠和2）两组 处于对热量限制的品系反应分布极端的重组近交系小鼠品系 (CR)一组菌株显示出对CR的响应的特征性寿命延长，另一组菌株显示出对CR的响应的特征性寿命延长。 导致寿命缩短的菌株。这一核心所带来的这些和其他进展强调了其 重要性作为一个发电机的考古发现。核心的具体目标如下： 1.繁殖和维持新的和已建立的啮齿动物模型，用于研究衰老和/或 与年龄有关的疾病。 进行遗传、营养或代谢操纵模型的寿命研究， 由NIA和其他资助来源资助的调查人员的要求。 为基线初步研究提供具有特殊生物学意义的动物模型。 向整个生殖医学界提供含有雷帕霉素和其他药物的饮食。 教育和建议教师，研究员，和学生对老龄化的特殊要求感兴趣， 畜牧业在老龄化研究中的作用

The purpose of the Aging Animal and Longevity Assessment Core is to provide Center investigators and researchers in aging outside the University with a broad spectrum of uniformly maintained, specific-pathogen free rodent models for the study of aging, according to their needs. The Core will continue to play a central role in the Nathan Shock Aging Center. All animals in the Core will be supported by NIA or other aging grants. The Core will breed, maintain and monitor aging rodent colonies, determine their longevity and age-related changes in weight, body composition and food intake, and distribute these animals to Center members and others for basic research on aging. In addition, the Core will maintain for pilot studies small populations of two murine models that Center investigators have recently found to have exceptional potential for understanding fundamental mechanisms of aging: 1) rapamycin-treated genetically heterogeneous mice and 2) two groups of recombinant inbred mouse strains at the extremes of the distribution of strain responses to calorie restriction (CR) ¿ one group of strains that shows characteristic life extension in response to CR and the other group of strains that responds with life shortening. These and other advances enabled by this Core underscore its importance as a generator of biogerontologic discovery. The Specific Aims of the Core are as follows: 1 To breed and maintain new and established rodent models for study of the mechanism of aging and/or age-related disease processes. To conduct lifespan studies of genetically, nutritionally, or pharmacologically manipulated models according to the requirements of investigators funded by the NIA and other granting sources. To provide animal models of exceptional biogerontological interest for baseline pilot studies. To provide diets containing rapamycin and other drugs to the biogerontological community at large. To educate and advise faculty, fellows, and students interested in aging on the special requirements of animal husbandry in aging research.