Biostatistic/Outcomes Cores

同种异体造血干细胞移植（HSCT）是许多恶性血液病和骨髓衰竭患者唯一的治疗方法。移植成功的关键障碍是移植物抗宿主病（GVHD）。本次更新申请的最终目标是进一步提高我们对aGVHD和cGVHD的病理生理学的理解，并在维持GVL的同时，针对这两种综合征的不同细胞群，开发预防和治疗cGVHD的新策略。关键是实现这一目标，从而导致

Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative therapy for many patients with hematologic malignancies and marrow failure. A critical hurdle in accomplishment of successful HSCT has been graft-versus-host disease (GVHD).The ultimate objective of the research projects in this renewal application is to further improve our understanding of the pathophysiology of aGVHD and cGVHD and to develop novel strategies for both prevention and therapy of cGVHD by targeting distinct cellular populations in these two syndromes while maintaining GVL. Key to achieve this objective and thus to lead to the success of this program project is dynamic biostatistical collaboration with individuals in each of the 3 projects and the 3 other Cores. The purpose of the Biostatistics Core C is to provide the following services that will be utilized by the research projects included in this Program Project. 1. To provide biostatistical collaboration for translational clinical research studies. 2. To provide biostatistical collaboration for translational animal research studies. 3. To provide biostatistical and/or bioinformatics collaboration for translational laboratory research studies. 4. To provide research infrastructure for translational research. 5. To provide computing resources for data processing, and statistical analysis, standardized reporting, and quality control.