Development Research Program

孢子发展研究计划的目标是促进针对孢子转化黑色素瘤研究的新思路。SPORE指南要求通过提供正式的发展研究计划（DRP）来努力确定和资助试点项目，该计划将突出和支持新的研究努力，无论是一个或多个SPORE内的科学家之间的合作，还是与SPORE环境外的新科学家合作，最终可能降低黑色素瘤患者的发病率和发病率或增加生存率。实验室和临床研究项目都有资格获得资助，尽管这些项目必须以转化为目标。NCI SPORE预算的一部分（每年75，000美元）将每年分配用于支持这些试点项目。通过医学博士提供的配套资金（每年为DRP和CDP各增加100，000美元），安德森作为其对SPORE的机构承诺的一部分，我们每年有175,000美元用于支持黑色素瘤的DRP。 在这4.5年中，SPORE DRP已经支持了36个黑色素瘤DRP奖项。每年提供的奖学金数目各不相同，取决于资金，主要是根据实际余额，因为以前资助的项目是否被批准第二年资助。我们的研究结果表明，SPORE基金大大增强和扩大了新项目的开发潜力，在项目进入完整的SPORE项目或竞争其他资金之前，需要提供初步数据。我们已经实现了DRP的具体目标。迄今为止资助的36个不同项目代表了来自医学博士16个不同部门和部门的调查人员。安德森以及我们邻近的机构，包括德州大学。加尔维斯顿的医疗分支。虽然我们的SPORE还很年轻，而且早期的获奖者刚刚看到了他们的资助成果，但这一努力已经取得了重大进展，包括4名DRP研究人员现在被列为完整项目的共同领导人，43份手稿提交和/或出版。共提交了21项赠款，其中14项获得资助，4项目前正在审查中。这些进展证明了SPORE发展研究计划对黑色素瘤研究的重要性和成功，以及我们在M.D.安德森。我们的计划是继续这一计划的征求建议，最高为50,000美元，并提供初步的 分期付款25，000美元，如果达到了最初的目标，并且可以向执行委员会和IAB委员会证明进展和需求，则再支付25，000美元。

The goal of the SPORE Development Research Program is to promote new ideas directed toward the SPORE translational melanoma research. SPORE guidelines mandate diligent efforts to identify and fund pilot projects by providing a formal Developmental Research Program (DRP) that will highlight and support new research endeavors, whether collaborative among scientists within one or more SPOREs, or with new scientists outside the SPORE environment, that may eventually reduce the incidence and morbidity or increase the survival of melanoma patients. Both laboratory and clinical research projects are eligible for funding although the projects must aim toward a translational goal. A portion of the NCI SPORE budget ($75,000 per year) will be allocated annually to support these pilot projects. With matching funds (an additional $100,000 per year for each the DRP and CDP) provided by the M.D. Anderson as part of its nstitutional commitment to the SPORE, we have had $175,000 each year to support the DRP in Melanoma. Over these 4.5 years the SPORE DRP has supported 36 DRP in melanoma awards. The number of awards offered each year varied, depending on funds, based in large part on the actual balance due to whether previously funded projects were approved for a second year of funding. Our results, show that SPORE funds greatly enhanced and expanded the potential for development of new projects in which preliminary data was required before the project could move to a full SPORE project, or compete for other funding. We have achieved the specific objectives of the DRP. The 36 different projects funded to date represent investigators from 16 different Departments and Divisions at M.D. Anderson as well as at our neighboring institutions, including the U.T. Medical Branch at Galveston. Although our SPORE is young, and the early awardees just now are seeing the results of their funding, this effort has led to significant progress including 4 DRP investigators now included as Co-Leaders of full projects, 43 manuscripts submitted, and/or published. Twenty-one grants were submitted with 14 of these receiving funding and 4 under review at this time. These advances are evidence of the importance and success of the SPORE Developmental Research Program to melanoma research overall as well as to our local efforts at M.D. Anderson. Our plans are to continue this program by solicitation of proposals for a maximum of $50,000 each, and provide the initial installment of $25,000 followed by an additional $25,000 if the initial goals are met and the progress and need can be justified to the Executive and lAB committees.