Developmental Research Program

太平洋西北地区发展研究计划（DRP）的主要目的 前列腺癌孢子是支持创新的转化前列腺癌（PC）研究试点项目 旨在降低PC所致的发病率和死亡率，并改善患者的生存率和生活质量。 PC患者在为减贫方案提供初步资金期间， 这一独特而成功的研究项目的实施。在DRP的前四年， 提交了46个试点项目提案，19个项目获得了资金（直接供资总额为798 100.00美元）。 到目前为止，该方案已出版了10本出版物，并提供了7笔赠款。对于这种连续补助金，DRP 该计划将继续提供一种机制，以快速响应新的转化研究机会 可能在参与机构的SPORE环境中开发的项目：温哥华总医院 (VGH)加拿大不列颠哥伦比亚省温哥华前列腺中心、华盛顿大学、 弗雷德哈钦森癌症研究中心（FHCRC）和系统生物学研究所（ISB）在西雅图， 华盛顿州;和，俄勒冈州健康科学大学（OHSU）在波特兰，或。DRP提供的支持将 继续允许开展创新试点项目，并期望这些项目能够成熟 使他们能够成功地从内部或外部的来源竞争额外的资金 spore grant.该计划还吸引了更多具有不同科学专业知识的高级研究人员， 转译PC研究的新研究者。《残疾人权利方案》的具体目标是： 1)征集创新的、转化的前列腺癌研究提案，以获得年度试点资金。 基础; 2)召集专家小组，对NIH之后的试点研究提案进行严格的科学审查 选择最有前途的研究项目的准则; 3)提供1 - 2年的试点研究资金，用于最具创新性的制药商发起的想法， 前列腺癌研究的所有领域的研究（包括病因学，预防，诊断，生物 机制，遗传学和治疗），特别强调解决问题的项目， 与提高疾病侵袭性或转移的知识相关;以及， 4)允许SPORE领导层将资金投向特别有可能推动 PNW前列腺癌的转化研究目标。

The main purpose of the Developmental Research Program (DRP) of the Pacific Northwest (PNW) Prostate Cancer SPORE is to support innovative translational prostate cancer (PC) research pilot projects aimed at reducing the morbidity and mortality due to PC and at improving the survival and quality of life of PC patients. During the initial funding of the DRP, substantial progress has been made in the development and implementation of this unique and successful research program. During the first four years of the DRP, 46 pilot project proposals were submitted and 19 projects were funded (total of $798,100.00 direct funding). Ten publications and 7 grants have resulted to date from the DRP. For this continuation grant, the DRP program will continue to provide a mechanism to quickly respond to new translational research opportunities that may develop within the SPORE environments of participating institutions: Vancouver General Hospital (VGH) Prostate Centre in Vancouver, British Columbia, Canada; the University of Washington (UW), the Fred Hutchinson Cancer Research Center (FHCRC), and the Institute for Systems Biology (ISB) in Seattle, WA; and, Oregon Health Sciences University (OHSU) in Portland, OR. Support provided by the DRP will continue to allow innovative pilot projects to be initiated, with the expectation that the projects will mature sufficiently so that they can successfully compete for additional funding from sources either within or outside the SPORE grant. This program also attracts more senior investigators with diverse scientific expertise and new investigators into translational PC research. The specific aims for the DRP are: 1) Solicit innovative, translational prostate cancer research study proposals for pilot funding on an annual basis; 2) Convene a panel of experts to provide rigorous scientific review of pilot study proposals following NIH guidelines for selection of the most promising research projects; 3) Provide pilot study funding for 1-2 years for the most innovative investigator-initiated ideas for research in all areas of prostate cancer research (including etiology, prevention, diagnosis, biological mechanisms, genetics, and treatment) with a special emphasis on projects that address issues relevant to advancing knowledge of disease aggressiveness or metastasis; and, 4) Allow the SPORE leadership to target funds to specific areas that are especially likely to advance the translational research goals of the PNW prostate cancer SPORE.