Mass Spectometry Facility Core

MS Facility Core的研发功能是协助用户开发新的分析方法。这些一般涉及定量技术的发展，以测量内源性代谢物，方法的发展，以提高样品电离和高性能UPLC方法的发展。如果这些内部项目旨在使更多的调查人员受益并提高设施核心工作人员的技术技能，则无需用户承担任何费用。 质谱（MS）设施核心的使命是为P30 EHS核心中心的中心研究员和试点及其他支持项目提供具有成本效益的最先进仪器和分析专业知识。该设施核心是利用位于大学范围内的质谱设施中的技术人员和仪器设施的专业服务核心之一，用于鉴定，定量，和小分子反应产物的表征，例如类二十烷酸和氧化脂质（1-3），DNA碱基加合物（4-7），修饰的寡核苷酸的鉴定和表征（8-10），以及异生物质毒物的代谢活化（1，11- 1 - 3）。

The research and development function of the MS Facility Core is to assist users with development of novel analytical methods. These generally relate to development of quantitative techniques to measure endogenous metabolites, development of methods to improve sample ionization and development of high performance UPLC methods. These internal projects are undertaken at no expense to users if they are intended to benefit a larger group of investigators and improve the technical skills of the facility core staff. The mission of the Mass Spectrometry (MS) Facility Core is to provide cost effective, state-of-the-art instrumentation and analytical expertise to Center Investigators and pilot and other supported projects in the P30 EHS Core Center This facility core is among the specialized service cores utilizing the technical personnel and instrument facilities located in the university-wide mass spectrometry facility and is used for identification, quantitation, and characterization of small molecule reaction products, e.g. eicosanoids and oxidized lipids (1-3), DNA base adducts (4-7), identification and characterization of modified oligonucleotides (8-10), and metabolic activation of xenobiotic toxicants (1, 11-13).