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Development of clinical candidate hypoxia-activated DNA-PK inhibitors

Development of clinical candidate hypoxia-activated DNA-PK inhibitors
临床候选缺氧激活 DNA-PK 抑制剂的开发
批准号：
490356
负责人：
Minchinton Andrew I
金额：
$71.33万
依托单位：
B.C. Cancer Research Centre (Vancouver)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2023
资助国家：
加拿大
项目状态：
未结题
起止时间：
2023-09-01 至 2027-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=490356&lang=en
关键词：
Chemotherapy Clinical Drug Development Dna Damage Repair Inhibitors Dna-Pk Hypoxia Prodrug Prodrugs Radiotherapy Screening Cascade Tumour Microenvironment

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Radiation and chemotherapy remain the principal treatments for inoperable cancers. Cancer cells are killed following these therapies, but some are resistant due to their ability to repair the DNA damage. Recently, drugs that can block a cancer cell's abil
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