Console for 4T Human MR System

描述（由申请人提供）：耶鲁大学磁共振研究中心是通过1H和13C MRS进行体内磁共振光谱（MRS）代谢研究的先驱和领导者。4.0T 94 cm Bruker系统一直是人体代谢研究的传统主力机，是MRRC唯一能够进行身体和大脑13C MRS研究的系统。目前，该系统支持15个学院的研究，其中9个主要用户获得了R01资助。NIH对用户组的支持是17项拨款：10项R01s， 4项中心拨款（R24， P30和两个p50）， 1项R21, 1项K02和1项STTR。大多数使用该系统的pi在他们的研究中使用MRS的经验超过10年。然而，新的实验方法的持续发展和突破性的疾病应用，已经成为系统研究项目的标志，严重损害了其8年历史的控制台和电子设备的有限能力和可靠性。为了维持用户组的生产力，我们建议将失败的Bruker Avance控制台替换为具有多个接收器功能的最先进的Agilent控制台。我们的选择是基于我们在操作和维护类似安捷伦控制台方面的丰富内部经验，并将它们与我们的家用射频线圈和梯度/垫片硬件以及系统的广泛MRS功能集成。新的控制台将允许多年来的可靠性能广泛的复杂代谢实验的用户组，并确保先进的13C和1H MRS方法的持续发展。

DESCRIPTION (provided by applicant): The Yale MRRC is a pioneer and leader in the in the study of metabolism by in vivo Magnetic Resonance Spectroscopy (MRS) by 1H and 13C MRS. The 4.0T 94 cm Bruker system has been the traditional workhorse for human metabolic studies and is the only system at the MRRC capable of 13C MRS studies of body and brain. At present the system supports the research of 15 faculty including 9 major users with R01 funding. The NIH support for the user group is 17 grants: 10 R01s, 4 Center grants (R24, P30, and two P50s), an R21, a K02, and an STTR. Most of the PIs using the system have over 10 years of experience using MRS in their research. However the continued development of novel experimental methodology and groundbreaking applications to disease, that have been the hallmark of the research program on system, are severely compromised by the limited capabilities and decreasing reliability of its 8 year old console and electronics. In order to sustain the productivity of the User group we propose to replace the failing Bruker Avance console with a state of the art Agilent console with multiple receiver capability. Our selection is based upon our extensive in house experience in operating and maintaining similar Agilent consoles and integrating them with our home built RF coils and gradient/shim hardware and the extensive MRS capabilities of the system. The new console will allow for years to come the reliable performance of a wide range of sophisticated metabolic experiments by the User group, and insure the continued development of advanced 13C and 1H MRS methods. PUBLIC HEALTH RELEVANCE: Magnetic Resonance Spectroscopy (MRS) is a unique technology that allows chemistry to be imaged throughout the human body. The requested new console for an existing MRS/MRI 4.0T scanner will greatly enhance the research of a highly productive group of NIH funded scientists studying aging, diabetes, neurological and psychiatric disease. Their work has direct relevance for finding new targets for disease treatment and using MRS to evaluate therapies.