Tulane Building Interdisciplinary Research Careers in Women's Health (BIRCWH)

描述（由申请人提供）：这是杜兰BIRCWH计划的竞争性更新申请，该计划成功地培训了一批种族/民族和专业多元化的跨学科研究人员，在妇女健康和提高妇女的认识在杜兰的健康研究在过去4年。我们现在建议在我们先前成功的基础上，扩大和加强BIRCWH计划基础。长期目标是增加妇女健康领域训练有素的文化能力强、独立的跨学科研究人员的数量和多样性，重点是心血管疾病和相关疾病领域的性别差异研究。该计划的重点是心血管疾病和相关疾病，因为心脏病对女性的影响，在整个研究范围内对心血管疾病性别差异的现有知识差距，以及杜兰大学对这一重点的重视。我们成功的职业发展计划的关键组成部分包括：1）针对特定学者需求量身定制的教学课程; 2）个性化的职业发展培训; 3）BIRCWH研讨会系列; 4）正在进行的工作会议; 5）所需的赠款写作和项目管理研讨会; 6）指导跨学科研究;和7）在研究培训中负责任的行为。创新的方法包括通过2个职业发展轨道（轨道1为研究经验有限的学者;轨道2为具有先前研究经验的学者）为学者定制计划，并为每个学者使用网络指导模式，包括基础科学和临床研究的专业知识。学者们立即接触到研究，并被引导尽早建立学术记录，并通过积极参与妇女健康研究日获得演讲和组织技能。增强的BIRCWH计划的新组成部分包括新学科的额外教师参与，通过网络指导增加基础科学家和临床研究人员之间的跨学科互动，加强与Xavier（一个历史上的黑人，研究密集度较低的机构）的合作，以及增强对机构资源的访问。学者们将学习前沿的研究方法和技能，从板凳（细胞，分子和遗传学），到床边（临床研究和临床试验）到人口（流行病学，预防和卫生服务研究），并在一个指导，跨学科的环境中建立实验室/研究小组进行自己的研究项目，解决最近的ORWH优先事项。学者的跨学科研究活动将侧重于CVD和相关疾病及其风险因素的性别差异，并解决首要主题（寿命，性/性别决定因素，健康差异和跨学科研究）。我们建议培训8名教师学者至少2-3年（3年最低的医生科学家）。持续和全面的评估将指导改进该计划在弥合研究培训和研究独立性方面所表现出的有效性，这些研究人员主要关注性别差异和心血管疾病。 公共卫生相关性：迫切需要在整个研究领域确定心血管疾病和相关疾病的性别差异，以改善健康状况，减少妇女保健的分散现象。为了最有效地解决妇女健康方面的重大问题，包括性别差异，需要有一支准备进行跨学科合作研究的多样化的工作队伍。为此，杜兰BIRCWH计划将为初级教师提供指导性的职业发展，以增加在心血管和相关疾病领域从事妇女健康研究的训练有素的独立调查人员的数量，重点是在整个生命周期中的性别差异研究。

DESCRIPTION (provided by applicant): This is a competing renewal application for the Tulane BIRCWH Program, which has successfully trained a racially/ethnically and professionally diverse group of interdisciplinary researchers in women's health and increased awareness of women's health research at Tulane over the last 4 years. We propose now to build on our prior success and expand and reinforce the BIRCWH program base. The long-term goal is to increase the number and diversity of highly trained culturally competent, independent, interdisciplinary investigators in Women's Health with an emphasis on Sex Differences research in the field of cardiovascular disease (CVD) and related diseases. The program focuses on CVD and related diseases because of the impacts of heart dis- ease on women, the existing knowledge gaps on the sex differences in CVD across the research spectrum, and the strength of this focus at Tulane. Key components of our successful career development plan include 1) didactic courses tailored to specific Scholar needs; 2) individualized career development training; 3) BIRCWH seminar series; 4) Work-in-Progress sessions; 5) required grant writing and project management workshops; 6) mentored interdisciplinary research; and 7) responsible conduct in research training. The innovative approach includes tailoring the program to Scholars needs via 2 career development tracks (Track 1 for Scholars with limited research experience; Track 2 for Scholars with prior research experience), and using a network mentoring model for each Scholar, including expertise in both basic science and clinical research. Scholars are immediately exposed to research and are guided to establish a scholarly track record early, and gain presentation and organization skills by active participation in the Women's Health Research day. New components of the enhanced BIRCWH program include additional faculty participation in new disciplines, in- creased interdisciplinary interactions between basic scientists and clinical researchers through network mentoring, strengthened collaboration with Xavier, a historically Black, less-research-intensive institution, and enhanced access to institutional resources. The Scholars will learn cutting-edge research methods and skills from Bench (cellular, molecular, and genetics), to Bedside (clinical research and clinical trials) to Population (epidemiology, prevention, and health services research) and conduct their own research projects in established laboratories/research groups in a mentored, interdisciplinary environment that address the most recent ORWH priorities. Scholar's interdisciplinary research activities will focus on sex differences in CVD and related diseases and their risk factors and address overarching themes (lifespan, sex/gender determinants, health disparities, and interdisciplinary research). We propose to train 8 faculty Scholars for a minimum of 2-3 years (3 years minimum for physician-scientists). Ongoing and comprehensive evaluation will guide improvements to the program's demonstrated effectiveness in bridging research training and research independence for junior investigators focused on Sex Differences and CVD. PUBLIC HEALTH RELEVANCE: There is a critical need to determine sex differences in cardiovascular and related diseases across the research spectrum in order to improve health and reduce the fragmentation in women's health care. In order to most effectively tackle the significant problems in women's health, including sex differences, there needs to be a diverse workforce prepared to undertake interdisciplinary, collaborative research. To this end, the Tulane BIRCWH program will provide mentored career development for junior faculty to increase the number of highly trained independent investigators engaged in women's health research in the field of cardiovascular and related diseases, with an emphasis on sex differences research across the lifespan.