DETERMINANTS OF SELF-RENEWAL, DIFFERENTIATION, AND REPROGRAMMING OF HESCS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 目的：由Slukvin博士领导的项目3的目标是识别对将成纤维细胞和血细胞重新编程为多能状态最关键的基因和表观遗传修饰。 该项目使用WNRPC干细胞资源。 出版物： 胡凯，于军，苏克农塔K，田S，蒙哥马利K，崔KD，斯图尔特R，汤姆森JA，Slukvin II。从正常和肿瘤骨髓和脐带血单个核细胞中高效地制备无转基因诱导的多能干细胞。血。2011年2月4日PMID：21296996

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: The goals of project 3, led by Dr. Slukvin, are to identify genes and epigenetic modifications most critical for reprogramming fibroblasts and blood cells to pluripotent state. This project uses WNRPC Stem Cell Resources. Publication: Hu K, Yu J, Suknuntha K, Tian S, Montgomery K, Choi KD, Stewart R, Thomson JA, Slukvin II. Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells. Blood. 2011 Feb 4. PMID: 21296996