2012 Biomolecular Interactions & Methods GRC&GRS

描述（由申请人提供）：本提案要求部分支持生物分子相互作用和方法戈登研究会议（GRC）及其相关的研究生研究研讨会（GRS），将于2012年1月14日至15日（GRS）和1月15日至20日（GRC）在德克萨斯州加尔维斯顿历史悠久的加尔维斯酒店举行。在过去的十年中，随着结构生物学、生物物理学、理论方法、单分子技术和系统生物学的令人兴奋的进展，我们对细胞过程的分子机制和时间的理解达到了新的水平。大型大分子复合物的结构、限速步骤的热力学和动力学描述、单分子在工作中的定量研究以及相互作用和相互作用网络建模的理论框架已经彻底改变了我们对生物分子相互作用与细胞功能和疾病之间关系的理解。拟议会议的主要目的是为信息交流提供一个国际论坛，以便更好地整合从原子解析结构到完整系统中的功能角色的知识。我们的重点是理解分子机制，从分子识别的初级过程到活细胞中的相互作用网络。科学范围包括：蛋白质相互作用和疾病；热力学和动力学；生物物理方法研究进展；计算方法的进展；绿色生物物理学;大分子机器和组件；分子网络动力学；以及单分子动力学。会议还旨在促进在各自领域处于领先地位的不同国际科学家群体之间的新合作。生物分子相互作用和方法（BIM）戈登研究会议的成功之处在于，它为一个相对较小但多样化的科学家群体提供了一个独特的机会，讨论支撑定量生物学研究的最新方法、结果和理论方法。通常最具想象力和创造性的新科学是来自不同背景的科学家之间合作的结果，而BIM GRC为科学家探索跨越科学学科和生物系统的想法和实验方法提供了理想的环境。

DESCRIPTION (provided by applicant): This proposal requests partial support for the Biomolecular Interactions and Methods Gordon Research Conference (GRC) and its associated Graduate Research Symposium (GRS), to be held at the historic Hotel Galvez in Galveston, Texas on January 14 - 15 (GRS) and January 15 - 20 (GRC), 2012. In the past decade, our understanding of the molecular mechanisms and timing of cellular processes has reached new levels, with exciting advances in structural biology, biophysics, theoretical approaches, single-molecule techniques, and systems biology. The structures of large macromolecular complexes, the thermodynamic and kinetic descriptions of rate-limiting steps, the quantitative study of single molecules at work, and the theoretical framework for modeling interactions and networks of interactions have revolutionized our understanding of relationships between biomolecular interactions and cellular function and disease. The principal purpose of the proposed conference is to provide an international forum for information exchange that will lead to better integration of knowledge from atomic resolution structures to functional roles in intact systems. Our focus is on understanding molecular mechanisms, from primary processes underlying molecular recognition, to interaction networks in living cells. The scientific scope encompasses: protein interactions and disease; thermodynamics and kinetics; advances in biophysical methods; advances in computational methods; green biophysics; macromolecular machines and assemblages; molecular network dynamics; and single-molecule dynamics. The conference also aims to catalyze new collaborations between a diverse group of international scientists who work at the leading edge in their respective fields. The highly successful aspect of the Biomolecular Interactions and Methods (BIM) Gordon Research Conference is that it provides a unique opportunity for a relatively small but diverse group of scientists to discuss the latest methods, results and theoretical approaches that underpin quantitative biological research. Often the most imaginative and creative new science is the result of collaboration between scientists from different backgrounds, and the BIM GRC provides an ideal environment for scientists to explore ideas and experimental approaches that cut across scientific disciplines and biological systems. PUBLIC HEALTH RELEVANCE: The structures of large macromolecular complexes, the thermodynamic and kinetic descriptions of rate-limiting steps, the quantitative study of single molecules at work, and the theoretical framework for modeling interactions and networks of interactions have revolutionized our understanding of relationships between biomolecular interactions and cellular function and disease. Often the most imaginative and creative new science is the result of collaboration between scientists from different backgrounds, and the proposed Biomolecular Interactions and Methods Gordon Research Conference/Graduate Research Symposium provides an ideal environment for scientists to explore ideas and experimental approaches that cut across scientific disciplines and biological systems.