2012 Angiotensin Gordon Research Conference and Gordon Research Seminar

描述（由申请人提供）：2012年血管紧张素戈登研究会议（GRC）和连续的戈登研究研讨会（GRS）将重点关注肾素血管紧张素系统（RAS）的关键未发表的发展，涵盖血管生成，癌症风险，RAS结构生物学，新型信号传导机制，干细胞功能和各种主动脉病变。主题将包括microRNA，内分泌RAS和表观遗传学，以及RAS在研究较少的靶组织如脂肪和骨骼肌中的调节。新的见解，从新的成像和分子技术，包括生物发光共振能量转移和纳米技术将提出。此外，将讨论RAS级联中最不了解的成员的最新发现，包括蛋白质受体，氨肽酶A和糜酶，以及RAS的新治疗靶点，包括癌症，抑郁症和多发性硬化症。GRS将与GRC相吻合，并将主要关注发育，免疫和炎症中的RAS。GRC和GRS的主要目标是：1）批判性地审查未发表的前沿数据，这些数据将基础科学与RAS的临床和转化研究交织在一起; 2）在科学会议期间，以及在用餐，休息，休闲和社交活动中，让所有参与者对研究结果和对未来影响的创造性思考进行自由坦率和分析性的讨论; 3）促进新的合作和跨学科的研究举措， 生物化学、分子和细胞生物学、神经科学、生理学和人类病理生理学等学科; 4）通过在GRC和通过由学生、受训人员和年轻研究人员组织并专门以学生、受训人员和年轻研究人员为特色的GRS举办的海报会议、简短演讲和旅行奖励竞赛，提供能见度机会，促进学生、受训人员和早期职业研究人员的独立科学事业。

DESCRIPTION (provided by applicant): The 2012 Angiotensin Gordon Research Conference (GRC) and contiguous Gordon Research Seminar (GRS) will focus on key unpublished developments in the renin angiotensin system (RAS) covering angiogenesis, cancer risk, RAS structural biology, novel signaling mechanisms, stem cell function and diverse aortic pathologies. Topics will include microRNA, the intracrine RAS and epigenetics and also regulation of the RAS in less studied target tissues such as adipose and skeletal muscle. New insights from novel imaging and molecular techniques including bioluminescence resonance energy transfer and nanotechnology will be presented. In addition, the latest findings on the least understood members of the RAS cascade including the protein receptor, aminopeptidase A, and chymase will be discussed as well as novel therapeutic targets of the RAS including cancer, depression and multiple sclerosis. The GRS will dovetail to the GRC and will primarily focus on the RAS in development, immunity and inflammation. The primary goals of the GRC and GRS are to: 1) critically examine cutting-edge unpublished data that intertwines basic science with clinical and translational research on the RAS; 2) engage all participants in unfettered frank and analytical discussion of research findings and creative speculation over future implications during the scientific sessions as well as at meals, breaks, and leisure and social activities; 3) foster new collaborative and cross-disciplinary research initiatives spanning the disciplines of biochemistry, molecular and cellular biology, neuroscience, physiology and human pathophysiology; 4) advance the independent scientific careers of students, trainees and early career investigators by providing visibility opportunities through poster sessions, short talks and travel award competitions at the GRC and through the GRS, which is organized by and specifically features students, trainees and young investigators.